Benzenepropanoic acid, b-hydroxy-b-methyl-

Base Information

• Chemical Name: Benzenepropanoic acid, b-hydroxy-b-methyl-
• CAS No.: 3759-31-7
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Hs Code.: 2918199090
• Mol file: 3759-31-7.mol

Synonyms:3-hydroxy-3-phenyl-butyric acid;β-Oxy-β-phenyl-buttersaeure;3-Hydroxy-3-phenyl-buttersaeure;β-Oxy-β-phenyl-propan-α-carbonsaeure;(+/-)-3-Hydroxy-3-phenyl-buttersaeure;(+/-)-3-hydroxy-3-phenyl-butyric acid;

Chemical Property of Benzenepropanoic acid, b-hydroxy-b-methyl-

Chemical Property:

• PSA: 57.53000
• LogP: 1.36880

Purity/Quality:

95% ^*data from raw suppliers

3-hydroxy-3-phenylbutanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid, b-hydroxy-b-methyl-

There total 16 articles about Benzenepropanoic acid, b-hydroxy-b-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-methyl-4-oxo-2,6-diphenyl-[1,3]oxazinane-3-carboxylic acid tert-butyl ester → 3-hydroxy-3-phenylbutanoic acid (3759-31-7)

Guidance literature:

With lithium hydroxide; water; In ethanol; at 20 ℃; for 3h;

DOI:10.1055/s-1999-2926

Reference yield: 78.0%

3-hydroxy-3-phenylbutanenitrile (14368-31-1) → 3-hydroxy-3-phenylbutanoic acid (3759-31-7)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In water; at 20 - 50 ℃; for 7h;

DOI:10.1021/ol035206u

Reference yield: 78.0%

Iodoacetic acid (64-69-7) + acetophenone (98-86-2) → 3-hydroxy-3-phenylbutanoic acid (3759-31-7)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; at 25 ℃; for 3.5h;

DOI:10.1021/jo060118j

upstream raw materials:

2-phenylpent-4-en-2-ol

ethyl 3-hydroxy-3-phenylbutyrate

acetic acid

acetophenone

Downstream raw materials:

(E)-3-phenyl-2-butenoic acid

isopropenylbenzene

(-)S β-hydroxy β-phenyl n-butanoate de methyle

(R)-3-hydroxy-3-phenylbutyric acid methyl ester