ethyl 3-hydroxy-3-phenylbutanoate

Base Information

• Chemical Name: ethyl 3-hydroxy-3-phenylbutanoate
• CAS No.: 2293-60-9
• Molecular Formula: C12H16 O3
• Molecular Weight: 208.257
• Mol file: 2293-60-9.mol

Synonyms:Hydrocinnamicacid, b-hydroxy-b-methyl-, ethyl ester (6CI,8CI);Ethyl 3-hydroxy-3-phenylbutanoate; Ethyl b-hydroxy-b-methylhydrocinnamate; NSC 4107; NSC 49327; b-Hydroxy-b-methylbenzenepropanoic acid ethyl ester

Chemical Property of ethyl 3-hydroxy-3-phenylbutanoate

Chemical Property:

• Vapor Pressure: 8.08E-05mmHg at 25°C
• Boiling Point: 327.6°C at 760 mmHg
• Flash Point: 135.8°C
• Density: 1.095g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 3-hydroxy-3-phenylbutanoate

There total 27 articles about ethyl 3-hydroxy-3-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

acetophenone (98-86-2) + ethyl iodoacetae (623-48-3) → ethyl 3-hydroxy-3-phenylbutyrate (2293-60-9)

Guidance literature:

With manganese; copper(l) iodide; trifluoroacetic acid; In acetonitrile; at 20 ℃; for 12h; Reagent/catalyst; Solvent; Inert atmosphere;

Reference yield: 95.0%

ethyl bromoacetate (105-36-2) + acetophenone (98-86-2) → ethyl 3-hydroxy-3-phenylbutyrate (2293-60-9)

Guidance literature:

With tellurium; cerium(III) chloride; phenyllithium; In diethyl ether; at 0 - 25 ℃; for 1h;

Reference yield: 95.0%

chloroacetic acid ethyl ester (105-39-5) + acetophenone (98-86-2) → ethyl 3-hydroxy-3-phenylbutyrate (2293-60-9)

Guidance literature:

With 1,2-bis-(diphenylphosphino)ethane; zinc(II) iodide; zinc; cobalt(II) chloride; In acetonitrile; at 20 ℃; for 2.5h;

DOI:10.1002/adsc.200600378

upstream raw materials:

ethyl bromoacetate

acetophenone

ethyl 1,1-dichloroacetate

chloroacetic acid ethyl ester

Downstream raw materials:

1,1,3-Triphenyl-butan-1,3-diol

Cl₄Nb(C₆H₅C(CH₃)(O)CH₂CO₂C₂H₅)

Cl₃Nb(C₆H₅C(CH₃)(O)CH₂CO₂C₂H₅)2

Zr(isopropanolate)(ethyl-β-oxy-β-phenylbutyrate)3