Technology Process of Butanedioic acid, 2-[[4-(phenylmethoxy)phenyl]methyl]-3-(2-propenyl)-,
4-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R,3S)-
There total 8 articles about Butanedioic acid, 2-[[4-(phenylmethoxy)phenyl]methyl]-3-(2-propenyl)-,
4-(1,1-dimethylethyl) 1-(phenylmethyl) ester, (2R,3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 76 percent / K2CO3 / dimethylformamide / 3 h / 80 °C
2.1: 98 percent / LiOH; H2O / tetrahydrofuran / 2 h / 20 °C
3.1: pivaloyl chloride; DIEA / tetrahydrofuran / 1 h / -30 °C
3.2: 60 percent / LiCl / tetrahydrofuran / -30 - 20 °C
4.1: diisopropylamine; n-BuLi / tetrahydrofuran / 1 h / -78 °C
4.2: 61 percent / tetrahydrofuran / -78 - 0 °C
5.1: 100 percent / LiOH; H2O2 / tetrahydrofuran; H2O / 3 h / 0 °C
6.1: LDA / tetrahydrofuran / 1 h / -78 °C
6.2: 84 percent / tetrahydrofuran / 0 - 5 °C
7.1: LDA; Et2AlCl / tetrahydrofuran / -78 - 20 °C
7.2: 7.69 g / DBU / benzene / 50 °C
With
lithium hydroxide; n-butyllithium; water; dihydrogen peroxide; diethylaluminium chloride; pivaloyl chloride; potassium carbonate; diisopropylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm0155502
- Guidance literature:
-
(2R,3R)-2-Allyl-3-(4-benzyloxy-benzyl)-succinic acid 1-tert-butyl ester;
With
diethylaluminium chloride; lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 - 20 ℃;
benzyl bromide;
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
benzene;
at 50 ℃;
Further stages.;
DOI:10.1021/jm0155502
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 100 percent / HCl / dioxane / 2 h / 20 °C
2.1: 76 percent / K2CO3 / dimethylformamide / 3 h / 80 °C
3.1: 98 percent / LiOH; H2O / tetrahydrofuran / 2 h / 20 °C
4.1: pivaloyl chloride; DIEA / tetrahydrofuran / 1 h / -30 °C
4.2: 60 percent / LiCl / tetrahydrofuran / -30 - 20 °C
5.1: diisopropylamine; n-BuLi / tetrahydrofuran / 1 h / -78 °C
5.2: 61 percent / tetrahydrofuran / -78 - 0 °C
6.1: 100 percent / LiOH; H2O2 / tetrahydrofuran; H2O / 3 h / 0 °C
7.1: LDA / tetrahydrofuran / 1 h / -78 °C
7.2: 84 percent / tetrahydrofuran / 0 - 5 °C
8.1: LDA; Et2AlCl / tetrahydrofuran / -78 - 20 °C
8.2: 7.69 g / DBU / benzene / 50 °C
With
hydrogenchloride; lithium hydroxide; n-butyllithium; water; dihydrogen peroxide; diethylaluminium chloride; pivaloyl chloride; potassium carbonate; diisopropylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm0155502
