2',3'-Dimethoxyacetophenone

Base Information

• Chemical Name: 2',3'-Dimethoxyacetophenone
• CAS No.: 38480-94-3
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Hs Code.: 2914509090
• European Community (EC) Number: 966-105-7
• DSSTox Substance ID: DTXSID20496825
• Nikkaji Number: J89.235A
• Wikidata: Q63392842
• Mol file: 38480-94-3.mol

Synonyms:2',3'-Dimethoxyacetophenone;38480-94-3;1-(2,3-DIMETHOXYPHENYL)ETHANONE;2,3-Dimethoxyacetophenone;1-(2,3-dimethoxyphenyl)ethan-1-one;Ethanone, 1-(2,3-dimethoxyphenyl)-;MFCD03424412;methyl dimethoxyphenyl ketone;SCHEMBL341046;DTXSID20496825;FODUVZQSLRHUMC-UHFFFAOYSA-N;2' pound not3'-Dimethoxyacetophenone;AKOS006279476;2',3'-Dimethoxyacetophenone, AldrichCPR;CS-13032;AM20040340;CS-0072442;FT-0688395;EN300-188345;A873833;Q63392842;F9994-0638;2 inverted exclamation marka,3 inverted exclamation marka-Dimethoxyacetophenone

Chemical Property of 2',3'-Dimethoxyacetophenone

Chemical Property:

• Melting Point: 29.5-51.5℃
• Boiling Point: 156-158℃
• PSA: 35.53000
• Density: 1.066±0.06 g/cm3(Predicted)
• LogP: 1.90640
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 180.078644241
• Heavy Atom Count: 13
• Complexity: 179

Purity/Quality:

97% ^*data from raw suppliers

2′,3′-Dimethoxyacetophenone Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=C(C(=CC=C1)OC)OC
• Uses: 2'',3''-Dimethoxyacetophenone is used as a reactant in the preparation and antileishmanial activity of quinazolinone hybrids.

Technology Process of 2',3'-Dimethoxyacetophenone

There total 17 articles about 2',3'-Dimethoxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%

2,3-dimethoxybenzonitrile (5653-62-3) + methylmagnesium bromide (75-16-1) → 2,3-dimethoxyacetophenone (38480-94-3)

Guidance literature:

2,3-dimethoxybenzonitrile; methylmagnesium bromide; In diethyl ether; for 16h; Inert atmosphere;

With water; acetic acid; In diethyl ether; water; for 0.5h;

Reference yield: 88.6%

1-(2,3-dimethoxyphenyl)-1-ethanol (6848-73-3) → 2,3-dimethoxyacetophenone (38480-94-3)

Guidance literature:

With silica gel; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 4h;

DOI:10.3390/molecules25010102

Reference yield: 57.2%

methyl magnesium iodide (917-64-6) + 2,3-dimethoxybenzonitrile (5653-62-3) → 2,3-dimethoxyacetophenone (38480-94-3) + 1-(2-hydroxy-3-methoxyphenyl)ethanone (703-98-0)

Guidance literature:

In diethyl ether; for 18h;

DOI:10.1248/cpb.53.547

upstream raw materials:

methyl magnesium iodide

2,3-dimethoxybenzonitrile

1-(2,3-dimethoxyphenyl)-1-ethanol

ethyl acetoacetate

Downstream raw materials:

2',3'-dihydroxyacetophenone

1-(2-hydroxy-3-methoxyphenyl)ethanone

3-ethyl-1,2-dimethoxybenzene

2-bromo-2’,3’-dimethoxyacetophenone