2,6-Diisopropylphenylcarbamic acid methyl ester

Base Information

• Chemical Name: 2,6-Diisopropylphenylcarbamic acid methyl ester
• CAS No.: 39076-23-8
• Molecular Formula: C₁₄H₂₁NO₂
• Molecular Weight: 235.326
• Mol file: 39076-23-8.mol

Synonyms:Methyl-N-[2,6-di-(isopropyl)-phenyl]-carbamat;(2,6-Diisopropyl-phenyl)-carbamic acid methyl ester;

Chemical Property of 2,6-Diisopropylphenylcarbamic acid methyl ester

Chemical Property:

• Boiling Point: 272.0±29.0 °C(Predicted)
• PKA: 13.80±0.70(Predicted)
• PSA: 38.33000
• Density: 1.027±0.06 g/cm3(Predicted)
• LogP: 4.18470

Purity/Quality:

99% ^*data from raw suppliers

METHYL-N-(2,6-DIISOPROPYLPHENYL)CARBAMATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Diisopropylphenylcarbamic acid methyl ester

There total 2 articles about 2,6-Diisopropylphenylcarbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + oxalyl dichloride (79-37-8) + 2,6-diisopropylbenzenamine (24544-04-5) → Methyl-N-<2,6-di-(isopropyl)-phenyl>-carbamat (39076-23-8)

Guidance literature:

oxalyl dichloride; 2,6-diisopropylbenzenamine; With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 5 - 10 ℃;

In 1,4-dioxane; 1,2-dichloro-benzene; at 130 ℃; for 3h;

methanol; With sodium methylate; In 1,4-dioxane; 1,2-dichloro-benzene; at 20 ℃; Further stages.;

DOI:10.1016/j.tetlet.2004.04.043

Reference yield:

methanol (67-56-1) + 2,6-diisopropylphenyl isocyanate (28178-42-9) → Methyl-N-<2,6-di-(isopropyl)-phenyl>-carbamat (39076-23-8)

Guidance literature:

Inert atmosphere;

DOI:10.1002/chem.200801882

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Methyl-N-<2,6-di-(isopropyl)-phenyl>-carbamat (39076-23-8) → Chloromethyl-(2,6-diisopropyl-phenyl)-carbamic acid methyl ester (39074-49-2)

Guidance literature:

With thionyl chloride;

upstream raw materials:

methanol

oxalyl dichloride

2,6-diisopropylbenzenamine

2,6-diisopropylphenyl isocyanate

Downstream raw materials:

Chloromethyl-(2,6-diisopropyl-phenyl)-carbamic acid methyl ester

Refernces

• 1、 Oh, Lynette M.,Spoors, P. Grant,Goodman, Richard M.. "A new and convenient in-situ method of generating phenyl isocyanates from anilines using oxalyl chloride". . p. 4769 - 4771. Retrieved 2007/10/03.