METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL

Base Information

• Chemical Name: METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL
• CAS No.: 392277-22-4
• Molecular Formula: C6H13NO.ClH
• Molecular Weight: 151.63400
• Mol file: 392277-22-4.mol

Synonyms:N-Methyltetrahydro-2H-pyran-4-amine hydrochloride;N-methyl-N-tetrahydro-2H-pyran-4-ylamine hydrochloride;N-Methyltetrahydro-2H-Pyran-4-Amine;

Chemical Property of METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL

Chemical Property:

• PSA: 21.26000
• LogP: 1.57770

Purity/Quality:

99%, ^*data from raw suppliers

Methyl(tetrahydro-pyran-4-yl)amineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL

There total 4 articles about METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.6%

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) + methylamine hydrochloride (593-51-1) → N-methyl-N-(tetrahydropyran-4-yl)amine hydrochloride (392277-22-4)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; triethylamine; In methanol; at 60 ℃; for 3h; under 3750.38 Torr; Reagent/catalyst; Time; Large scale;

DOI:10.1021/op010052o

Reference yield: 50.0%

N-[(4-nitrophenyl)methyl]tetrahydro-N-methyl-2H-pyran-4-amine (229007-08-3) → 4-[[N-methyl-N-(tetrahydro-2H-pyran-4-yl)amino]methyl]aniline dihydrochloride + N-methyl-N-(tetrahydropyran-4-yl)amine hydrochloride (392277-22-4) + p-toluidine hydrochloride (540-23-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 0.15h; under 760.051 Torr;

DOI:10.1002/adsc.200600521

Reference yield: 26.0%

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) + methylamine (74-89-5) → N-methyl-N-(tetrahydropyran-4-yl)amine hydrochloride (392277-22-4)

Guidance literature:

Tetrahydro-4H-pyran-4-one; methylamine; With titanium(IV) isopropylate; In ethanol; at 20 ℃; for 5h;

With sodium tetrahydroborate; In ethanol; for 2h;

With hydrogenchloride; In diethyl ether;

upstream raw materials:

N-[(4-nitrophenyl)methyl]tetrahydro-N-methyl-2H-pyran-4-amine

Tetrahydro-4H-pyran-4-one

methylamine hydrochloride

methylamine

Downstream raw materials:

N-[(4-nitrophenyl)methyl]tetrahydro-N-methyl-2H-pyran-4-amine

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