10-chloro-11b-phenyl-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one

Base Information

• Chemical Name: 10-chloro-11b-phenyl-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one
• CAS No.: 24143-15-5
• Molecular Formula: C17H15 Cl N2 O2
• Molecular Weight: 314.7662

Synonyms:

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Chemical Property of 10-chloro-11b-phenyl-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one

Chemical Property:

• Vapor Pressure: 6.16E-10mmHg at 25°C
• Boiling Point: 495°C at 760 mmHg
• Flash Point: 253.1°C
• Density: 1.41g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 10-chloro-11b-phenyl-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one

There total 4 articles about 10-chloro-11b-phenyl-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxirane (75-21-8,99932-75-9) + ammonium hydroxide (1336-21-6) + desmethyldiazepam (1088-11-5) → 10-chloro-11b-phenyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one (24143-15-5)

Guidance literature:

aluminium trichloride; In dichloromethane; benzene;

Reference yield:

2-(2-bromoacetamido)-5-chloro-benzophenone (32580-26-0) + ethanolamine (141-43-5) → 10-chloro-11b-phenyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one (24143-15-5)

Guidance literature:

Multistep reaction; (i) CH₂Cl₂, (ii) AcOH, EtOH;

DOI:10.1021/jm00288a015

Reference yield:

7-Chloro-4-(2-hydroxy-ethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-4-ium → 10-chloro-11b-phenyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one (24143-15-5)

Guidance literature:

With borate buffer (pH=8-10.5); In ethanol; water; Equilibrium constant; Mechanism; variation of pH and buffers.;

DOI:10.1248/cpb.30.3810

upstream raw materials:

2-(2-bromoacetamido)-5-chloro-benzophenone

ethanolamine

oxirane

ammonium hydroxide

Downstream raw materials:

10-chloro-7-(2-hydroxyethyl)-2,3,5,11b-tetrahydro-11b-phenyloxazolo[3,2-d] [1,4]benzodiazepin-6-(7H)-one

10-chloro-7-(2-chloro-benzyl)-11b-phenyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one

10-chloro-7-ethyl-11b-phenyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one