393590-62-0Relevant academic research and scientific papers
7-(MORPHOLIN-4-YL)PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES WHICH ARE USEFUL FOR THE TREATMENT OF IMMUNE OR INFLAMMATORY DISEASES OR CANCER
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, (2017/07/31)
A compound of the general formula (I) wherein Y represents -CH2- or >C=0; R1 is selected from the group consisting of A1, A2 and A3; R2 represents dioxothiomorpholino moiety B1, piperazinyl moiety B2, azetidinyl moiety B3, or piperidinyl moiety B4; R3 is selected from the group consisting of H, halogen, and C1 -C4 alkyl; R4 is selected from the group consisting of C1 -C4 alkyl, C3-C4- cycloalkyl, C1 -C4 alkyl substituted with C1 -C4 alkoxy, and CHF2, and their pharmaceutically acceptable salts. Pharmaceutical compositions comprising said compounds and their use in the treatment of diseases of immune system, inflammatory diseases and cancer.
HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2
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, (2009/10/21)
The present invention relates to compounds of formula (I) wherein R1, R2, X, Y and Z are as defined in the specification.
A novel approach for the development of selective Cdk4 inhibitors: Library design based on locations of Cdk4 specific amino acid residues
Honma,Yoshizumi,Hashimoto,Hayashi,Kawanishi,Fukasawa,Takaki,Ikeura,Ikuta,Suzuki-Takahashi,Hayama,Nishimura,Morishima
, p. 4628 - 4640 (2007/10/03)
Identification of a selective inhibitor for a particular protein kinase without inhibition of other kinases is critical for use as a biological tool or drug. However, this is very difficult because there are hundreds of homologous kinases and their kinase
