ChloroMethyl Methyl Carbonate

Base Information

• Chemical Name: ChloroMethyl Methyl Carbonate
• CAS No.: 40510-81-4
• Molecular Formula: C3H5ClO3
• Molecular Weight: 124.524
• Hs Code.: 2920909090
• European Community (EC) Number: 849-140-1
• UNII: A3Y4CDQ6XX
• DSSTox Substance ID: DTXSID80564019
• Nikkaji Number: J830.091G
• Wikidata: Q82448585
• Mol file: 40510-81-4.mol

Synonyms:chloromethyl methyl carbonate;

Chemical Property of ChloroMethyl Methyl Carbonate

Chemical Property:

• Refractive Index: 1.41160 (589.3 nm 22℃)
• Boiling Point: 139-140℃ (760 Torr)
• PSA: 35.53000
• Density: 1.303 g/cm3 (15℃)
• LogP: 0.96570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Acetonitrile (Slightly), Chloroform, Methanol (Slightly)
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 123.9927217
• Heavy Atom Count: 7
• Complexity: 63.2

Purity/Quality:

97% ^*data from raw suppliers

Chloromethyl methyl carbonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)OCCl
• Uses: ChloroMethyl Methyl Carbonate is a reagent used in the preparation of prodrugs of diacidic nonpeptide angiotensin II antagonist as well as pyrrolothiazole platelet activating factor antagonist. A reagent used in the preparation of prodrugs of diacidic nonpeptide angiotensin II antagonist as well as pyrrolothiazole platelet activating factor antagonist.

Technology Process of ChloroMethyl Methyl Carbonate

There total 5 articles about ChloroMethyl Methyl Carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.8%

methanol (67-56-1) + carbonochloridic acid, chloromethyl ester (22128-62-7) → chloromethyl methyl carbonate (40510-81-4)

Guidance literature:

With pyridine; at 0 - 20 ℃;

Reference yield:

carbonochloridic acid, chloromethyl ester (22128-62-7) → chloromethyl methyl carbonate (40510-81-4)

Guidance literature:

In methanol;

Reference yield:

potassium carbonate (584-08-7) + carbonochloridic acid, chloromethyl ester (22128-62-7) → chloromethyl methyl carbonate (40510-81-4)

Guidance literature:

In methanol; dichloromethane;

upstream raw materials:

carbonic acid dimethyl ester

methanol

carbonochloridic acid, chloromethyl ester

potassium carbonate

Downstream raw materials:

Phenylthiomethyl-methyl-carbonat

piperidine-1-carboxylic acid methyl ester

methyl N-benzylcarbamate

methoxycarbonyloxymethyl 4-ethyl-2-propyl-1-[[2'-(N-triphenylmethyl(tetrazol-5-yl))biphenyl-4-yl]methyl]imidazole-5-carboxylate