Benzeneacetonitrile, a-hydroxy-a-methyl-

Base Information

• Chemical Name: Benzeneacetonitrile, a-hydroxy-a-methyl-
• CAS No.: 20102-12-9
• Molecular Formula: C9H9NO
• Molecular Weight: 147.177
• Mol file: 20102-12-9.mol

Synonyms:2-Hydroxy-2-phenyl-propionitrile;2-hydroxy-2-phenylpropanenitrile;acetophenone cyanohydrin;2-Hydroxy-2-phenyl-propionitril;

Chemical Property of Benzeneacetonitrile, a-hydroxy-a-methyl-

Chemical Property:

• Boiling Point: 170 °C(Press: 0.05 Torr)
• PSA: 44.02000
• Density: 1.127±0.06 g/cm3(Predicted)
• LogP: 1.41768

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetonitrile, a-hydroxy-a-methyl-

There total 16 articles about Benzeneacetonitrile, a-hydroxy-a-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trimethylsilyl cyanide (7677-24-9) + acetophenone (98-86-2) → 2-hydroxy-2-phenylpropionitrile (20102-12-9)

Guidance literature:

trimethylsilyl cyanide; acetophenone; With zinc(II) iodide; In dichloromethane; at 20 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1021/jm020546r

Reference yield: 87.0%

trimethylsilyl cyanide (7677-24-9) + acetophenone (98-86-2) → 2-hydroxy-2-phenylpropionitrile (20102-12-9) + 2-phenyl-2-trimethylsilyloxypropanenitrile (127462-20-8,25438-38-4)

Guidance literature:

With trimethylsilyl bis(trifluoromethanesulfonyl)imide; In dichloromethane; at -78 ℃; for 0.75h;

DOI:10.1080/00397919608003546

Reference yield: 34.0%

trimethylsilyl cyanide (7677-24-9) + acetophenone (98-86-2) → 2-hydroxy-2-phenylpropionitrile (20102-12-9) + 2-chloro-2-phenylpropanenitrile (69573-35-9)

Guidance literature:

With titanium tetrachloride; 1.) CH₂Cl₂, 0 deg C; 2.) CH₂Cl₂, RT, 24 h;

DOI:10.1246/cl.1984.1979

upstream raw materials:

ethanol

hydrogen cyanide

acetophenone

sodium cyanide

Downstream raw materials:

2-phenyl-2-(phenylamino)propanenitrile

1-piperidin-1-yl-ethanone

1-cyano-1-phenylethyl acetate

α-[(4-methoxyphenyl)amino]-α-methylbenzeneacetonitrile