2-Methyl-4-methylthiophenylboronic acid

Base Information

• Chemical Name: 2-Methyl-4-methylthiophenylboronic acid
• CAS No.: 444722-03-6
• Molecular Formula: C8H11BO2S
• Molecular Weight: 182.051
• Mol file: 444722-03-6.mol

Synonyms:2-methyl-4-methylthiophenyl boronic acid;2-methyl-4-methylthiophenylboronic acid;[2-methyl-4-(methylthio)phenyl]boronic acid;

Chemical Property of 2-Methyl-4-methylthiophenylboronic acid

Chemical Property:

• Boiling Point: 339.6±52.0 °C(Predicted)
• PKA: 8.63±0.58(Predicted)
• PSA: 65.76000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 0.39670

Purity/Quality:

99% ^*data from raw suppliers

[2-Methyl-4-(methylsulfanyl)phenyl]boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 2-Methyl-4-methylthiophenylboronic acid

There total 1 articles about 2-Methyl-4-methylthiophenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

1-bromo-2-methyl-4-methylsulfanylbenzene (90532-02-8) → 2-methyl-4-(methylsulfanyl)phenylboronic acid (444722-03-6)

Guidance literature:

1-bromo-2-methyl-4-methylsulfanylbenzene; With tert.-butyl lithium; In diethyl ether; at -78 ℃; for 0.283333h;

With Trimethyl borate; In diethyl ether; at -78 - 20 ℃; for 0.283333h;

With hydrogenchloride; ammonium chloride; more than 3 stages;

Reference yield: 94.0%

trifluoromethanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-yl ester (648904-46-5) + 2-methyl-4-(methylsulfanyl)phenylboronic acid (444722-03-6) → 1-(2-{4-[6-methoxy-2-(2-methyl-4-methylsulfanyl-phenyl)-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine (648905-32-2)

Guidance literature:

trifluoromethanesulfonic acid 6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-yl ester; 2-methyl-4-(methylsulfanyl)phenylboronic acid; With cesium fluoride; In acetonitrile; Heating / reflux;

palladium diacetate; tricyclohexylphosphine; In acetonitrile; at 90 ℃; for 0.666667h;

Reference yield: 82.0%

2-methyl-4-(methylsulfanyl)phenylboronic acid (444722-03-6) + tert-butyl 4-(((6-bromopyridin-3-yl)oxy)methyl)piperidine-1-carboxylate (1032825-09-4) → 1,1-dimethylethyl 4-[({6-[2-methyl-4-(methylthio)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate (1032825-85-6)

Guidance literature:

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; at 80 ℃; for 2h;

upstream raw materials:

1-bromo-2-methyl-4-methylsulfanylbenzene

Downstream raw materials:

1-(2-{4-[6-methoxy-2-(2-methyl-4-methylsulfanyl-phenyl)-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

5-[2-methyl-4-(methylthio)phenyl]-2-pyrazinamine

1,1-dimethylethyl 4-[({6-[2-methyl-4-(methylthio)phenyl]-3-pyridinyl}oxy)methyl]-1-piperidinecarboxylate

5-[({1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl}methyl)oxy]-2-[2-methyl-4-(methylthio)phenyl]pyridine

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