Technology Process of Cyclohexanecarboxylic acid, 1-ethyl-, methyl ester
There total 4 articles about Cyclohexanecarboxylic acid, 1-ethyl-, methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl cyclohexylcarboxylate;
With
n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at 0 ℃;
for 2h;
ethyl iodide;
In
tetrahydrofuran; hexane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sulfuric acid / 48 h / Reflux
2.1: n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide / tetrahydrofuran; hexane / 2 h / 0 °C
2.2: 20 °C
With
n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
sulfuric acid;
In
tetrahydrofuran; hexane;
- Guidance literature:
-
methyl cyclohexylcarboxylate;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
ethyl bromide;
In
tetrahydrofuran;
at -78 - 20 ℃;
DOI:10.1002/anie.201311263