2-Oxa-4,8,13-triazatetradecan-14-oic acid, 8-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-3-[4-(phenylmeth oxy)phenyl]propyl]-3-oxo-1-phenyl-, phenylmethyl ester

Base Information

Chemical Name:2-Oxa-4,8,13-triazatetradecan-14-oic acid, 8-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-3-[4-(phenylmeth oxy)phenyl]propyl]-3-oxo-1-phenyl-, phenylmethyl ester
CAS No.:500228-03-5
Molecular Formula:C44H54N4O8
Molecular Weight:766.935
Hs Code.:

2-Oxa-4,8,13-triazatetradecan-14-oic acid,
8-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-3-[4-(phenylmeth
oxy)phenyl]propyl]-3-oxo-1-phenyl-, phenylmethyl ester

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Chemical Property of 2-Oxa-4,8,13-triazatetradecan-14-oic acid, 8-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-3-[4-(phenylmeth oxy)phenyl]propyl]-3-oxo-1-phenyl-, phenylmethyl ester

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Technology Process of 2-Oxa-4,8,13-triazatetradecan-14-oic acid, 8-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-3-[4-(phenylmeth oxy)phenyl]propyl]-3-oxo-1-phenyl-, phenylmethyl ester

There total 1 articles about 2-Oxa-4,8,13-triazatetradecan-14-oic acid, 8-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-3-[4-(phenylmeth oxy)phenyl]propyl]-3-oxo-1-phenyl-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 89965-56-0
<3-<<4-(carboxyamino)butyl>amino>propyl>carbamic acid, dibenzyl ester

: 500228-03-5
(+)-{4-{{3-{[(Benzyloxy)carbonyl]amino}propyl}{(2S)-3-[(4-benzyloxy)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoyl}amino}butyl}carbaminsaeure-benzylester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; at 20 ℃; for 2h;
DOI:10.1002/hlca.200390015

Reference yield: 100.0%

: 500228-03-5
(+)-{4-{{3-{[(Benzyloxy)carbonyl]amino}propyl}{(2S)-3-[(4-benzyloxy)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoyl}amino}butyl}carbaminsaeure-benzylester

: 500228-04-6
(+)-{{4-{(2S)-2-Amino-3-[4-(benzyloxy)phenyl]propanoyl}{3-{[(benzyloxy)carbonyl]amino}propyl}amino}butyl}carbonsaeure-benzylester

Guidance literature:: With trifluoroacetic acid; In toluene; at 20 ℃; for 1h;
DOI:10.1002/hlca.200390015

Reference yield:

: 500228-03-5
(+)-{4-{{3-{[(Benzyloxy)carbonyl]amino}propyl}{(2S)-3-[(4-benzyloxy)phenyl]-2-{[(tert-butoxy)carbonyl]amino}propanoyl}amino}butyl}carbaminsaeure-benzylester

: (+)-(2S,3S)-3-{{(1S)-1-[(4-Aminobutyl)(3-aminopropyl)carbamoyl]-2-(4-hydroxyphenyl)ethyl}carbamoyl}oxiran-2-carbonsaeure

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / trifluoroacetic acid / toluene / 1 h / 20 °C

2: 88 percent / HOBT; DCC / ethyl acetate / 2 h / 20 °C

3: 91 percent / KOH / ethanol / 1 h / 20 °C

4: 90 percent / H₂ / Pd/C / ethanol / 15 h / 20 °C / 2625.21 Torr

With potassium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In ethanol; ethyl acetate; toluene;
DOI:10.1002/hlca.200390015