1-Methoxy-2-naphthaldehyde

Base Information

• Chemical Name: 1-Methoxy-2-naphthaldehyde
• CAS No.: 50493-10-2
• Molecular Formula: C12H10O2
• Molecular Weight: 186.20700
• European Community (EC) Number: 865-825-8
• DSSTox Substance ID: DTXSID00519460
• Nikkaji Number: J2.244.493J
• Wikidata: Q82382665
• Mol file: 50493-10-2.mol

Synonyms:1-methoxy-2-naphthaldehyde;50493-10-2;1-Methoxynaphthalene-2-carbaldehyde;1-Methoxynaphthalene-2-carboxaldehyde;1-methoxy-naphthalene-2-carbaldehyde;MFCD17012300;SCHEMBL3563735;DTXSID00519460;VPMICVLTBHRPNL-UHFFFAOYSA-N;1-methoxy-2-naphthalenecarboxaldehyde;AKOS022505508;AS-63320;SY205384;CS-0061935;EN300-226206;Z1255363268

Chemical Property of 1-Methoxy-2-naphthaldehyde

Chemical Property:

• Melting Point: 61-63 °C
• Boiling Point: 347.1±15.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.169±0.06 g/cm3(Predicted)
• LogP: 2.66090
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 186.068079557
• Heavy Atom Count: 14
• Complexity: 203

Purity/Quality:

97% ^*data from raw suppliers

1-methoxynaphthalene-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC2=CC=CC=C21)C=O

Technology Process of 1-Methoxy-2-naphthaldehyde

There total 14 articles about 1-Methoxy-2-naphthaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(Hydroxymethyl)-1-methoxynaphthalene (76635-76-2) → 1-methoxy-2-naphthaldehyde (50493-10-2)

Guidance literature:

With dipyridinium dichromate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2008.04.134

Reference yield: 91.0%

1-hydroxy-2-naphthaldehyde (574-96-9) + methyl iodide (74-88-4) → 1-methoxy-2-naphthaldehyde (50493-10-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1021/acs.joc.7b00486

Reference yield: 85.0%

difluoromethyl phenyl sulfide (1535-67-7) + 1-Methoxynaphthalene (2216-69-5) → 1-methoxy-2-naphthaldehyde (50493-10-2)

Guidance literature:

difluoromethyl phenyl sulfide; 1-Methoxynaphthalene; With tin(IV) chloride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In water; dimethyl sulfoxide; at 20 ℃; for 2h;

DOI:10.1055/s-0036-1591545

upstream raw materials:

2-allyl-1-methoxynaphthalene

(Z)-2-Azido-3-(1-methoxy-naphthalen-2-yl)-acrylic acid ethyl ester

N-methyl-N-phenylformamide

1-Methoxynaphthalene

Downstream raw materials:

(E)-1-(4-biphenyl)-3-(1-methoxynaphthalen-2-yl)prop-2-en-1-one

(E)-1-(4-bromophenyl)-3-(1-methoxynaphthalen-2-yl)prop-2-en-1-one

(E)-1-(3-nitrophenyl)-3-(1-methoxynaphthalen-2-yl)prop-2-en-1-one

(E)-1-(4-chlorophenyl)-3-(1-methoxynaphthalen-2-yl)prop-2-en-1-one