1,2-Ethanediamine, 1,2-bis(4-methoxyphenyl)-

Base Information

• Chemical Name: 1,2-Ethanediamine, 1,2-bis(4-methoxyphenyl)-
• CAS No.: 51208-43-6
• Molecular Formula: C16H20N2O2
• Molecular Weight: 272.34200
• Mol file: 51208-43-6.mol

Synonyms:1,2-Bis(4'-methoxyphenyl)ethan-1,2-diamin;1,2-bis(4-methoxyphenyl)ethylenediamine;1,2-bis-(4-methoxy-phenyl)-ethylenediamine;(+/-)-1,2-bis(4-methoxyphenyl)ethylenediamine;meso-1,2-bis(4-methoxyphenyl)ethylenediamine;dl-1,2-bis(4-methoxyphenyl)ethylenediamine;1,2-Bis-(4-methoxy-phenyl)-ethane-1,2-diamine;

Chemical Property of 1,2-Ethanediamine, 1,2-bis(4-methoxyphenyl)-

Chemical Property:

• PSA: 70.50000
• LogP: 3.80420

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Ethanediamine, 1,2-bis(4-methoxyphenyl)-

There total 5 articles about 1,2-Ethanediamine, 1,2-bis(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-methoxy-benzaldehyde (123-11-5) → meso-1,2-bis-(p-methoxyphenyl)-ethylenediamine (51208-43-6,117106-36-2)

Guidance literature:

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; ammonia; scandium tris(trifluoromethanesulfonate); In methanol; acetonitrile; at 0 - 25 ℃; for 15h; chemoselective reaction; Sealed tube; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.8b01637

Reference yield: 53.0%

N-trimethylsilyl-(4-methoxybenzaldimine) (132127-28-7) → meso-1,2-bis-(p-methoxyphenyl)-ethylenediamine (51208-43-6,117106-36-2)

Guidance literature:

With titanium tetrachloride; magnesium; In tetrahydrofuran; Ambient temperature;

DOI:10.1002/hlca.19880710818

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → meso-1,2-bis-(p-methoxyphenyl)-ethylenediamine (51208-43-6,117106-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) hexamethyldisilazane, BuLi / 1) THF, hexane, 40 min, RT; 2) THF, hexane, 2 h

2: 53 percent / Mg, TiCl₄ / tetrahydrofuran / Ambient temperature

With n-butyllithium; titanium tetrachloride; magnesium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran;

DOI:10.1002/hlca.19880710818

upstream raw materials:

meso-N,N'-bis(4-methoxybenzylidene)-1,2-bis(4-methoxyphenyl)ethylenediamine

N-trimethylsilyl-(4-methoxybenzaldimine)

4-methoxy-benzaldehyde

Downstream raw materials:

2-amino-1,2-dianisylethanol

meso-1,2-bis(4-hydroxyphenyl)ethylenediamine

(+/-)-1,2-bis(4-hydroxyphenyl)ethylenediamine dihydrobromide

meso-N,N'-bis(4-methoxybenzylidene)-1,2-bis(4-methoxyphenyl)ethylenediamine