Formamide, N,N'-(methylenedi-4,1-phenylene)bis-

Base Information

• Chemical Name: Formamide, N,N'-(methylenedi-4,1-phenylene)bis-
• CAS No.: 52721-83-2
• Molecular Formula: C15H14N2O2
• Molecular Weight: 254.288
• European Community (EC) Number: 665-349-9
• DSSTox Substance ID: DTXSID90400858
• Nikkaji Number: J1.957.138F
• Wikidata: Q82203907
• Mol file: 52721-83-2.mol

Synonyms:52721-83-2;Formamide, N,N'-(methylenedi-4,1-phenylene)bis-;SCHEMBL6434819;DTXSID90400858;AKOS024324144;4-[4-(formylamino)benzyl]phenylformamide;N,N'-[Methylenebis(4,1-phenylene)]bis(formamide)

Chemical Property of Formamide, N,N'-(methylenedi-4,1-phenylene)bis-

Chemical Property:

• PSA: 65.18000
• LogP: 3.71300
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 254.105527694
• Heavy Atom Count: 19
• Complexity: 252

Purity/Quality:

4',4''-METHYLENEBIS(FORMANILIDE) Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)NC=O)NC=O

Technology Process of Formamide, N,N'-(methylenedi-4,1-phenylene)bis-

There total 3 articles about Formamide, N,N'-(methylenedi-4,1-phenylene)bis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

formic acid (64-18-6) + 4,4'-diamino diphenyl methane (101-77-9) → N,N'-(methylenebis(4,1-phenylene))diformamide (52721-83-2)

Guidance literature:

With Na⁺-MMT-[pmim]HSO₄; In neat (no solvent); at 60 ℃; for 1h; chemoselective reaction;

DOI:10.1007/s11164-015-2116-0

Reference yield: 41.0%

Methyl formate (107-31-3) + 4,4'-diamino diphenyl methane (101-77-9) → N-[4-(4-aminobenzyl)phenyl]formamide + N,N'-(methylenebis(4,1-phenylene))diformamide (52721-83-2)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 24h; Green chemistry;

DOI:10.1039/d0gc02412k

Reference yield:

4,4'-diamino diphenyl methane (101-77-9) + formic acid ethyl ester (109-94-4) → N,N'-(methylenebis(4,1-phenylene))diformamide (52721-83-2)

Guidance literature:

In tetrahydrofuran; at 55 ℃; for 48h; Inert atmosphere;

DOI:10.1016/j.bmcl.2010.12.132

upstream raw materials:

4,4'-diamino diphenyl methane

formic acid ethyl ester

formic acid

Methyl formate

Downstream raw materials:

N,N'-dimethyl-N,N'-(methylenedi-4,1-phenylene)bis(2-bromoacetamide)

N,N'-dimethyl-N,N'-(methylenedi-4,1-phenylene)bis[2-(1-pyrrolidinyl)acetamide]

4,4'-methylenebis(N-methylaniline)

octaethyl methylenediphenyl-4,4`-bis[aminomethylidene(bisphosphonate)]

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