(2Z)-3-Amino-3-phenyl-2-propenoic acid ethyl ester

Base Information

• Chemical Name: (2Z)-3-Amino-3-phenyl-2-propenoic acid ethyl ester
• CAS No.: 53256-19-2
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Mol file: 53256-19-2.mol

Synonyms:ethyl 3-amino-3-phenyl-2-propenoate;2-Propenoic acid,3-amino-3-phenyl-,ethyl ester,(2Z);(Z)-3-amino-3-phenylacrylic acid ethyl ester;(Z)-ethyl 3-amino-3-phenylacrylate;3-amino-3-phenylacrylic acid ethyl ester;ethyl (Z)-3-amino-3-phenylacrylate;

Chemical Property of (2Z)-3-Amino-3-phenyl-2-propenoic acid ethyl ester

Chemical Property:

• Boiling Point: 164-165 °C(Press: 10 Torr)
• PKA: 3.93±0.70(Predicted)
• PSA: 52.32000
• Density: 1.099
• LogP: 2.24960

Purity/Quality:

98%Min ^*data from raw suppliers

(Z)-3-Amino-3-phenyl-acrylicacidethylester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2Z)-3-Amino-3-phenyl-2-propenoic acid ethyl ester

There total 13 articles about (2Z)-3-Amino-3-phenyl-2-propenoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) → ethyl (Z)-3-amino-3-phenylacrylate (53256-19-2)

Guidance literature:

With ammonium acetate; tetraethoxy orthosilicate; In ethanol; Heating;

DOI:10.1039/b419254k

Reference yield: 95.0%

→ ethyl (Z)-3-amino-3-phenylacrylate (53256-19-2)

Guidance literature:

Reference yield: 90.0%

ethyl bromoacetate (105-36-2) + benzonitrile (100-47-0) → ethyl (Z)-3-amino-3-phenylacrylate (53256-19-2)

Guidance literature:

With zinc(II) oxide; zinc; In tetrahydrofuran; for 2h; Irradiation; sonochemical reaction;

DOI:10.1016/S0040-4039(96)02321-0

upstream raw materials:

ethyl trans-3-phenyl-4,5-dihydro-5-(2-hydroxyphenyl)-4-isoxazolecarboxylate

ethyl 3-oxo-3-phenylpropionate

ethyl acetate

benzonitrile

Downstream raw materials:

(E)-4-[1-Amino-1-phenyl-meth-(Z)-ylidene]-pent-2-enedioic acid 5-ethyl ester 1-methyl ester

(2Z,4Z)-5-Amino-4-ethoxycarbonyl-3-methoxycarbonyl-5-phenyl-penta-2,4-dienoic acid methyl ester

(E)-4-[1-Amino-1-phenyl-meth-(Z)-ylidene]-pent-2-enedioic acid diethyl ester

3-ethoxycarbonyl-2-phenyldioxopyrroline