2-Chlorobenzoic acid phenacyl ester

Base Information

• Chemical Name: 2-Chlorobenzoic acid phenacyl ester
• CAS No.: 55153-25-8
• Molecular Formula: C15H11ClO3
• Molecular Weight: 274.704
• Mol file: 55153-25-8.mol

Synonyms:2-Chlor-benzoesaeure-phenacylester;2-oxo-2-phenylethyl 2-chlorobenzoate;Phenacyl-o-chlorbenzoat;2-chloro-benzoic acid phenacyl ester;2-CHLOROBENZOIC ACID PHENACYL ESTER;

Chemical Property of 2-Chlorobenzoic acid phenacyl ester

Chemical Property:

• Boiling Point: 438.8±25.0 °C(Predicted)
• PSA: 43.37000
• Density: 1.276±0.06 g/cm3(Predicted)
• LogP: 3.37970

Purity/Quality:

2-CHLOROBENZOIC ACID PHENACYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chlorobenzoic acid phenacyl ester

There total 5 articles about 2-Chlorobenzoic acid phenacyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

potassium 2-chlorobenzoate (16463-38-0) + α-bromoacetophenone (70-11-1) → 2-(2-chlorobenzoyloxy)-1-phenylethanone (55153-25-8)

Guidance literature:

dibenzo-18-crown-6; tetrabutylammomium bromide; In acetonitrile; for 2h; Ambient temperature;

Reference yield: 90.0%

1-phenyl-2-(p-tolylsulfonyloxy)ethanone (7257-94-5) + potassium 2-chlorobenzoate (16463-38-0) → 2-(2-chlorobenzoyloxy)-1-phenylethanone (55153-25-8)

Guidance literature:

With 1-butyl-3-methylimidazolium Tetrafluoroborate; at 20 ℃; for 0.333333h;

Reference yield:

acetophenone (98-86-2) → 2-(2-chlorobenzoyloxy)-1-phenylethanone (55153-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-butyl-3-methylimidazolium tetrafluoroborate / 0.67 h / 80 °C

2: 90 percent / 1-butyl-3-methylimidazolium tetrafluoroborate / 0.33 h / 20 °C

With 1-butyl-3-methylimidazolium Tetrafluoroborate;

upstream raw materials:

α-bromoacetophenone

ortho-chlorobenzoic acid

sodium 2-chlorobenzoate

potassium 2-chlorobenzoate

Downstream raw materials:

acetophenone

Refernces

• 1、 Chen, Jianzhong,Liu, Delong,Butt, Nicholas,Li, Chao,Fan, Dongyang,Liu, Yangang,Zhang, Wanbin. "Palladium-catalyzed asymmetric hydrogenation of α-acyloxy-1- arylethanones". supporting information. p. 11632 - 11636. Retrieved 2013/11/06.
• 2、 Jugdale,Patil,Salunkhe. "Synthesis of phenacyl esters by using PTC and dibenzo-[18)-crown-6". . p. 1747 - 1752. Retrieved 2007/10/03.