4-(chloromethyl)-1,3-diphenyl-1H-pyrazole

Base Information

Chemical Name:4-(chloromethyl)-1,3-diphenyl-1H-pyrazole
CAS No.:55432-05-8
Molecular Formula:C16H13ClN2
Molecular Weight:268.746
Hs Code.:
DSSTox Substance ID:DTXSID90368146
Wikidata:Q82154495

Synonyms:4-(chloromethyl)-1,3-diphenyl-1H-pyrazole;55432-05-8;4-(chloromethyl)-1,3-diphenylpyrazole;4-Chloromethyl-1,3-diphenyl-1H-pyrazole;1H-Pyrazole, 4-(chloromethyl)-1,3-diphenyl-;4-(chloromethyl)-1,3-diphenyl-pyrazole;Enamine_001660;SCHEMBL953073;DTXSID90368146;KIJMYHFMHWASDT-UHFFFAOYSA-N;HMS1398L10;MFCD02714800;AKOS000117511;CS-10771;CS-0230598;FT-0729909;EN300-10468

Suppliers and Price of 4-(chloromethyl)-1,3-diphenyl-1H-pyrazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 4-(chloromethyl)-1,3-diphenyl-1H-pyrazole

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:268.0767261
Heavy Atom Count:19
Complexity:272

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=NN(C=C2CCl)C3=CC=CC=C3

Technology Process of 4-(chloromethyl)-1,3-diphenyl-1H-pyrazole

There total 5 articles about 4-(chloromethyl)-1,3-diphenyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 40278-32-8
4-hydroxymethyl-1H-1,3-diphenylpyrazole

: 55432-05-8
4-(chloromethyl)-1,3-diphenyl-1H-pyrazole

Guidance literature:: With thionyl chloride; In benzene; for 2h; Heating;
DOI:10.1023/A:1016346528487

Reference yield:

: 21487-45-6
1,3-diphenyl-4-formylpyrazole

: 55432-05-8
4-(chloromethyl)-1,3-diphenyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / sodium tetrahydridoborate / ethanol / 1 h

2: 87 percent / thionyl chloride / benzene / 2 h / Heating

With sodium tetrahydroborate; thionyl chloride; In ethanol; benzene;
DOI:10.1023/A:1016346528487

Reference yield:

: 100-63-0
phenylhydrazine

: 55432-05-8
4-(chloromethyl)-1,3-diphenyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid

2: trichlorophosphate / 2 h / 90 °C

3: sodium tetrahydroborate / ethanol / 1 h / 20 °C

4: thionyl chloride / toluene / 2 h / 115 °C

With sodium tetrahydroborate; thionyl chloride; acetic acid; trichlorophosphate; In ethanol; toluene; 2: |Vilsmeier-Haack Formylation;
DOI:10.1021/acs.jmedchem.7b01562