(1,3-Diphenyl-1h-pyrazol-4-yl)-methanol

Base Information

• Chemical Name: (1,3-Diphenyl-1h-pyrazol-4-yl)-methanol
• CAS No.: 40278-32-8
• Molecular Formula: C16H14N2O
• Molecular Weight: 250.3
• Hs Code.: 2933199090
• DSSTox Substance ID: DTXSID30353410
• Nikkaji Number: J2.621.791A
• Wikidata: Q82130997
• ChEMBL ID: CHEMBL4211723
• Mol file: 40278-32-8.mol

Synonyms:40278-32-8;(1,3-diphenyl-1h-pyrazol-4-yl)-methanol;(1,3-Diphenyl-1H-pyrazol-4-yl)methanol;(1,3-diphenylpyrazol-4-yl)methanol;Enamine_001145;CHEMBL4211723;SCHEMBL11249366;DTXSID30353410;HMS1397E01;SMSF0009600;(1,3-diphenyl-4-pyrazolyl)methanol;MFCD01909793;AKOS000115746;CB00933;CCG-305124;1,3-Diphenyl-4-(hydroxymethyl)pyrazole;CS-10773;CS-0355034;EN300-03010;A825132;SR-01000469709;J-500095;SR-01000469709-1;Z56787637

Chemical Property of (1,3-Diphenyl-1h-pyrazol-4-yl)-methanol

Chemical Property:

• Vapor Pressure: 2.92E-09mmHg at 25°C
• Refractive Index: 1.621
• Boiling Point: 460.1 °C at 760 mmHg
• PKA: 13.88±0.10(Predicted)
• Flash Point: 232 °C
• PSA: 38.05000
• Density: 1.15 g/cm³
• LogP: 3.03160
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 250.110613074
• Heavy Atom Count: 19
• Complexity: 272

Purity/Quality:

99%, ^*data from raw suppliers

(1,3-Diphenyl-1H-pyrazol-4-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NN(C=C2CO)C3=CC=CC=C3

Technology Process of (1,3-Diphenyl-1h-pyrazol-4-yl)-methanol

There total 11 articles about (1,3-Diphenyl-1h-pyrazol-4-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,3-diphenyl-4-formylpyrazole (21487-45-6) → 4-hydroxymethyl-1H-1,3-diphenylpyrazole (40278-32-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.5h;

DOI:10.1002/aoc.6514

Reference yield:

sodium bis(2-methoxyethoxy)aluminium dihydride (22722-98-1) + 1,3-diphenyl-4-formylpyrazole (21487-45-6) → 4-hydroxymethyl-1H-1,3-diphenylpyrazole (40278-32-8)

Guidance literature:

With hydrogenchloride; In water; benzene;

Reference yield:

acetophenone (98-86-2) → 4-hydroxymethyl-1H-1,3-diphenylpyrazole (40278-32-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium acetate / ethanol / 3 h / 50 - 60 °C

2: trichlorophosphate / 6 h / 50 - 60 °C

3: sodium tetrahydroborate / dichloromethane / 8 h / Reflux

With sodium tetrahydroborate; sodium acetate; trichlorophosphate; In ethanol; dichloromethane;

DOI:10.1039/c4ra05257a

upstream raw materials:

propargyl alcohol

N-phenylbenzohydrazonoyl chloride

1,3-diphenyl-4-formylpyrazole

sodium bis(2-methoxyethoxy)aluminium dihydride

Downstream raw materials:

4-(chloromethyl)-1,3-diphenyl-1H-pyrazole

1,3-diphenyl-4-formylpyrazole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 40278-32-8 (1,3-DIPHENYL-1H-PYRAZOL-4-YL)-METHANOL

Send

Send

Metric Ton KG G Pound L ML

Send

Send