Ethyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate

Base Information

• Chemical Name: Ethyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate
• CAS No.: 55899-18-8
• Molecular Formula: C11H12N2O2
• DSSTox Substance ID: DTXSID80480503
• Wikidata: Q82315306

Synonyms:ethyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate;55899-18-8;SCHEMBL1290693;DTXSID80480503;ethyl6-methylpyrazolo[1,5-a]pyridine-3-carboxylate

Chemical Property of Ethyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 204.089877630
• Heavy Atom Count: 15
• Complexity: 245

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=C2C=CC(=CN2N=C1)C

Technology Process of Ethyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate

There total 3 articles about Ethyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

1-amino-3-methylpyridin-1-ium iodide (7583-91-7) + propynoic acid ethyl ester (623-47-2) → ethyl 4-methylpyrazolo[1,5-a]pyridine-3-carboxylate (55899-17-7) + ethyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate (55899-18-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2011.05.126

Reference yield: 21.0%

3-Methylpyridine (108-99-6) + propynoic acid ethyl ester (623-47-2) → ethyl 4-methylpyrazolo[1,5-a]pyridine-3-carboxylate (55899-17-7) + ethyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate (55899-18-8)

Guidance literature:

3-Methylpyridine; With mesitylenesulfonylhydroxylamine; In dichloromethane; at 0 ℃; for 2h;

propynoic acid ethyl ester; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/j.bmc.2011.11.029

Reference yield:

3-Methylpyridine (108-99-6) → ethyl 4-methylpyrazolo[1,5-a]pyridine-3-carboxylate (55899-17-7) + ethyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate (55899-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen iodide; hydroxylamine-O-sulfonic acid / water / 20 - 87 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With hydrogen iodide; potassium carbonate; hydroxylamine-O-sulfonic acid; In water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.05.126

upstream raw materials:

3-Methylpyridine

1-amino-3-methylpyridin-1-ium iodide

propynoic acid ethyl ester

Downstream raw materials:

6-methylpyrazolo[1,5-a]pyridine-3-carboxylic acid

N,2-dimethyl-N'-((6-methylpyrazolo[1,5-a]pyridin-3-yl)methylene)-5-nitrobenzenesulfonohydrazide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 55899-18-8 Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 6-methyl-, ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send