(+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID

Base Information Edit

Chemical Name:(+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID
CAS No.:56135-03-6
Molecular Formula:C₁₀H₉F₃O₃
Molecular Weight:234.175
Hs Code.:
Mol file:56135-03-6.mol

Synonyms:MOSHER ACID;2-METHOXY-2-PHENYL-3,3,3-TRIFLUOROPROPIONIC ACID;Benzeneacetic acid, α-methoxy-α-(trifluoromethyl)-;3,3,3-trifluoro-2-methoxy-2-phenyl-propionic acid;RARECHEM AL BO 0073;2-METHOXY-2-PHENYL-3-TRIFLUOROPROPANOIC ACID;MTPA;

Suppliers and Price of (+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
α-Methoxy-α-(trifluoromethyl)phenylacetic acid 97%
1g
$ 42.90

Total 7 raw suppliers

Chemical Property of (+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID Edit

Chemical Property:

Melting Point:41-46oC(lit.)
Refractive Index:n20/D 1.476(lit.)
Boiling Point:95-98oC0.05 mm Hg(lit.)
Flash Point:>230 °F
PSA：46.53000
LogP:2.17520
Storage Temp.:2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

α-Methoxy-α-(trifluoromethyl)phenylacetic acid 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Uses Diastereomeric bis-esters of (±)-trans-7,8-dihydroxy-7,8,9,10-tetrahydrobenzo[α]pyrene with MTPA has been used as a noncarcinogenic precursor to obtain the (+)and (-)-dihydrodiols by chromatographic resolution. It has also been used to develop empirically derived correlation of configuration and nmr chemical shifts for diastereomeric MTPA esters.

Technology Process of (+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID

There total 32 articles about (+/-)-ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1044204-03-6
(S,R)-4-phenyl-3-(2-methoxy-2-phenyl-2-trifluoromethyl-acetyl)oxazolidin-2-one

: 1044204-62-7
C₁₈H₁₈F₃NO₃

: 17257-71-5,20445-31-2,56135-03-6,81655-41-6
(S)-Mosher acid

: 90319-52-1,7480-32-2
(4R)-phenyl-2-oxazolidinone

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 20 ℃; for 12h;
DOI:10.1016/j.tetasy.2008.04.032

Reference yield: 78.0%

: 52356-17-9
(S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanol

: 17257-71-5,20445-31-2,56135-03-6,81655-41-6
(S)-Mosher acid

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; In phosphate buffer; acetonitrile; at 55 ℃; for 4h;
DOI:10.1016/S0957-4166(03)00023-5

Reference yield:

: 20445-31-2,56135-03-6,81655-41-6,17257-71-5
MTPA

: 20445-31-2
R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

: 17257-71-5,20445-31-2,56135-03-6,81655-41-6
(S)-Mosher acid

Guidance literature:: MTPA; With (1S,2R)-1-amino-2-indanol; In ethanol; ethyl acetate; at 30 ℃; for 12h;

With hydrogenchloride; Further stages.;