64163-09-3

Usage

Physical state

Yellow to light brown solid

Usage

Building block in pharmaceutical and agricultural industries

Classification

Pyrazine class of organic compounds

Common use

Intermediate in the synthesis of medications and agrochemicals

Known for

Potential as an antibacterial and antifungal agent

Handling precautions

May pose health and environmental risks if not properly managed

Upstream product

• 64163-16-2 5-chloro-6-phenyl-1H-pyrazin-2-one 
• 102653-50-9 5-chloro-3-phenyl-2(1H)-pyrazinone 
• 98993-82-9 5-bromo-3-phenyl-1H-pyrazin-2-one 
• 99073-52-6 5-nitro-3-phenyl-1H-pyrazin-2-one 
• 10025-87-3 trichlorophosphate 
• 105985-16-8 2-amino-N-hydroxy-2-phenyl-acetamide 
• 58861-89-5 2-phenylpyrazine N⁽¹⁾-oxide 
• 58861-94-2 2-phenylpyrazine 4-oxide 
• 860410-57-7 2-chloro-5-methoxy-3-phenylpyrazine 
• 99984-69-7 3-methoxy-2-phenyl-pyrazine-1-oxide 
• 66769-60-6 3-chloro-5-phenylpyrazine 1-oxide 
• 66769-58-2 3-chloro-2-phenylpyrazine-1-oxide 
• 107378-30-3 N-Carbamoylmethyl-2-oxo-2-phenyl-acetamide 
• 105985-15-7 1-hydroxy-3-phenyl-2(1H)-pyrazinone 

Downstream Products

• 100142-71-0 2,5-dimethoxy-3-phenyl-pyrazine 
• 98948-89-1 3-bromo-5-chloro-6-phenyl-1H-pyrazin-2-one 
• 102653-50-9 5-chloro-3-phenyl-2(1H)-pyrazinone 
• 64163-16-2 5-chloro-6-phenyl-1H-pyrazin-2-one 
• 108771-65-9 N,N'-diacetyl-3-phenyl-2,5-piperazinedione 
• 108771-63-7 2-acetoxy-5-methoxy-3-phenylpyrazine 
• 108771-64-8 2-acetoxy-5-methoxy-6-phenylpyrazine 
• 103860-45-3 2-hydroxy-5-methoxy-6-phenylpyrazine 
• 21746-02-1 3-phenyl-2,5-diketopiperazine 
• 104092-52-6 5-chloro-2-methoxy-3-phenyl-pyrazine 
• 860410-57-7 2-chloro-5-methoxy-3-phenylpyrazine 

Relevant academic research and scientific papers

Studies on Pyrazines. 14. The Syntheses of 2,5-Dihydroxypyrazines and Their Derivatives

Reaction of phenylglycinamide (1c) with ethyl benzoylformate (2c) in the presence of refluxing ethanolic sodium ethoxide gave 2,5-dihydroxy-3,6-diphenylpyrazine (3i) in 19percent yield.This synthetic method, howewer, was limited to the preparation of 3i.On the other hand, α-aminoamides 1 condensed with α-ketoesters 2 to give the intermediates 5, which were also prepared by condensation of 1 with α-ketalesters 6, followed by hydrolysis of the ketal moeity.Cyclization of 5 with refluxing methanolic sodium methoxide gave only disubstituted 2,5-dihydroxypyrazines 3.Acetylation of 5 with refluxing acetic anhydride/acetic acid led to direct formation of 2,5-diacetoxypyrazines 9.Similarly, compounds 5 could be converted into 2,5-dichloropyrazines 4.

Studies on Pyrazines. 13. Chlorination of 1-Hydroxy-2(1H)-pyrazinones with Phosphoryl Chloride. Formation of 2,5-Dichloro-3-phenylpyrazine from 1-Hydroxy-3-phenyl-2(1H)-pyrazinone

The chlorination of 1-hydroxy-3-phenyl-2(1H)-pyrazinone with phosphoryl chloride proceeded to 5-chloro-3-phenyl-2(H)-pyrazinone or 2,5-dichloro-3-phenylpyrazine on heating to elevated temperatures.To define the mechanism of the novel formation, reactions

Some Reactions of Mono Substituted Pyrazine Monoxides

The reactions of the monoxides of propylpyrazine and phenylpyrazine with phosphoryl chloride or acetic anhydride were investigated.Except in the case of the reaction of 2-propylpyrazine 1-oxide with acetic anhydride, chlorination or acetoxylation occurred