64163-09-3

Basic information

• Product Name: 2,5-dichloro-6-phenylpyrazine
• Synonyms: 2,5-dichloro-6-phenylpyrazine
• CAS NO: 64163-09-3
• Molecular Weight: 225.077
• Mol File: 64163-09-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,5-dichloro-6-phenylpyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dichloro-6-phenylpyrazine(64163-09-3)
• EPA Substance Registry System: 2,5-dichloro-6-phenylpyrazine(64163-09-3)

Safety Data

• Hazardous Substances Data: 64163-09-3(Hazardous Substances Data)

Usage

Physical state

Yellow to light brown solid

Usage

Building block in pharmaceutical and agricultural industries

Classification

Pyrazine class of organic compounds

Common use

Intermediate in the synthesis of medications and agrochemicals

Known for

Potential as an antibacterial and antifungal agent

Handling precautions

May pose health and environmental risks if not properly managed

Upstream product

• 100-34-5 benzene diazonium chloride 
• 99984-69-7 3-methoxy-2-phenyl-pyrazine-1-oxide 
• 860410-57-7 2-chloro-5-methoxy-3-phenylpyrazine 
• 104092-52-6 5-chloro-2-methoxy-3-phenyl-pyrazine 
• 99984-63-1 2-methoxy-3-phenylpyrazine 
• 2882-18-0 3-phenyl-2(1H)-pyrazinone 
• 58861-94-2 2-phenylpyrazine 4-oxide 
• 58861-89-5 2-phenylpyrazine N⁽¹⁾-oxide 
• 41270-59-1 6-phenyl-1H-pyrazin-2-one 
• 2882-18-0 2-hydroxy-3-phenylpyrazine 
• 58861-87-3 2-chloro-3-phenyl-pyrazine 4-oxide 
• 41270-62-6 2-chloro-6-phenylpyrazine 
• 29460-97-7 2-phenylpyrazine 
• 160315-09-3 2-acetoxy-3-phenylpyrazine 

Downstream Products

• 98948-89-1 3-bromo-5-chloro-6-phenyl-1H-pyrazin-2-one 
• 102653-50-9 5-chloro-3-phenyl-2(1H)-pyrazinone 
• 64163-16-2 5-chloro-6-phenyl-1H-pyrazin-2-one 
• 108771-65-9 N,N'-diacetyl-3-phenyl-2,5-piperazinedione 
• 108771-63-7 2-acetoxy-5-methoxy-3-phenylpyrazine 
• 108771-64-8 2-acetoxy-5-methoxy-6-phenylpyrazine 
• 103860-45-3 2-hydroxy-5-methoxy-6-phenylpyrazine 
• 21746-02-1 3-phenyl-2,5-diketopiperazine 
• 100142-71-0 2,5-dimethoxy-3-phenyl-pyrazine 
• 104092-52-6 5-chloro-2-methoxy-3-phenyl-pyrazine 
• 860410-57-7 2-chloro-5-methoxy-3-phenylpyrazine 

Relevant articles and documents

Studies on Pyrazines. 14. The Syntheses of 2,5-Dihydroxypyrazines and Their Derivatives

Reaction of phenylglycinamide (1c) with ethyl benzoylformate (2c) in the presence of refluxing ethanolic sodium ethoxide gave 2,5-dihydroxy-3,6-diphenylpyrazine (3i) in 19percent yield.This synthetic method, howewer, was limited to the preparation of 3i.On the other hand, α-aminoamides 1 condensed with α-ketoesters 2 to give the intermediates 5, which were also prepared by condensation of 1 with α-ketalesters 6, followed by hydrolysis of the ketal moeity.Cyclization of 5 with refluxing methanolic sodium methoxide gave only disubstituted 2,5-dihydroxypyrazines 3.Acetylation of 5 with refluxing acetic anhydride/acetic acid led to direct formation of 2,5-diacetoxypyrazines 9.Similarly, compounds 5 could be converted into 2,5-dichloropyrazines 4.

Studies on Pyrazines. Part 10. Substitution Effect on Reaction of Pyrazine N-Oxides with Phosphoryl chloride

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