N-Pyridin-2-ylmethyl-formamide

Base Information

• Chemical Name: N-Pyridin-2-ylmethyl-formamide
• CAS No.: 56625-03-7
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.153
• DSSTox Substance ID: DTXSID20481413
• Nikkaji Number: J1.928.449B
• Wikidata: Q82316815
• Mol file: 56625-03-7.mol

Synonyms:N-(2-Pyridylmethyl)formamide;N-Pyridin-2-ylmethyl-formamide;56625-03-7;N-(pyridin-2-ylmethyl)formamide;MFCD18384425;2-formamidomethylpyridine;SCHEMBL399162;N-(2-pyridinyl)methylformamide;DTXSID20481413;MMLVHQNFESMBKX-UHFFFAOYSA-N;n-((pyridin-2-yl)methyl)formamide;AC6369;AKOS006351299;AS-5909;SY236692;A923914

Chemical Property of N-Pyridin-2-ylmethyl-formamide

Chemical Property:

• Vapor Pressure: 5.7E-05mmHg at 25°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 136.063662883
• Heavy Atom Count: 10
• Complexity: 106

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)CNC=O

Technology Process of N-Pyridin-2-ylmethyl-formamide

There total 11 articles about N-Pyridin-2-ylmethyl-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(Aminomethyl)pyridine (3731-51-9) + formic acid ethyl ester (109-94-4) → N-((pyridin-2-yl)methyl)formamide (56625-03-7)

Guidance literature:

for 1.5h; Reflux;

DOI:10.1016/j.tet.2018.11.070

Reference yield: 99.0%

2-(Aminomethyl)pyridine (3731-51-9) + carbon dioxide (124-38-9,18923-20-1) → N-((pyridin-2-yl)methyl)formamide (56625-03-7)

Guidance literature:

With C₃₂H₃₆ClNO₂P₂Ru; hydrogen; In tetrahydrofuran; at 120 ℃; for 20h; under 30402 Torr; Autoclave; Green chemistry;

Reference yield: 98.0%

2-(Aminomethyl)pyridine (3731-51-9) + carbon monoxide (201230-82-2) → N-((pyridin-2-yl)methyl)formamide (56625-03-7)

Guidance literature:

With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In toluene; at 100 ℃; for 20h; under 22502.3 Torr; Autoclave;

DOI:10.1002/adsc.201900185

upstream raw materials:

2-(Aminomethyl)pyridine

formic acid

formic acid ethyl ester

formyl acetic anhydride

Downstream raw materials:

2-(N-Methyl-N-formyl-aminomethyl)-pyridin

N-methyl-2-pyridinemethanamine

imidazo[1,5-a]pyridine

1-acetylimidazo<1,5-a>pyridine