3-(2,2-Diacetylvinyl)-4H-1-benzopyran-4-one

Base Information

• Chemical Name: 3-(2,2-Diacetylvinyl)-4H-1-benzopyran-4-one
• CAS No.: 57443-91-1
• Molecular Formula: C15H12O4
• Molecular Weight: 256.258
• DSSTox Substance ID: DTXSID30446533
• Nikkaji Number: J1.047.413B
• Mol file: 57443-91-1.mol

Synonyms:CTK1F2027;3-(2,2-Diacetylvinyl)-4H-1-benzopyran-4-one;57443-91-1;DTXSID30446533

Chemical Property of 3-(2,2-Diacetylvinyl)-4H-1-benzopyran-4-one

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 256.07355886
• Heavy Atom Count: 19
• Complexity: 468

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C(=CC1=COC2=CC=CC=C2C1=O)C(=O)C

Technology Process of 3-(2,2-Diacetylvinyl)-4H-1-benzopyran-4-one

There total 2 articles about 3-(2,2-Diacetylvinyl)-4H-1-benzopyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Formylchromone (17422-74-1) + acetylacetone (123-54-6,81235-32-7) → 3-<(4-Oxo-4H-1-benzopyran-3-yl)-methylene>pentan-2,4-dione (57443-91-1) + (2-hydroxyphenyl)-(3'-acetyl-4'-hydroxyphenyl)-methanone (124208-69-1)

Guidance literature:

With hydrogenchloride; Yield given; Multistep reaction; 1.) AcOH, from 70 deg C to 80 deg C, 15 min, 2.) AcOH, from 70 deg C to 80 deg C, 2 h;

DOI:10.1039/a804173c

Reference yield:

3-formyl-6-methylchromone (42059-81-4) + acetylacetone (123-54-6,81235-32-7) → 3-<(4-Oxo-4H-1-benzopyran-3-yl)-methylene>pentan-2,4-dione (57443-91-1) + (2-hydroxyphenyl)-(3'-acetyl-4'-hydroxyphenyl)-methanone (124208-69-1)

Guidance literature:

With hydrogenchloride; Multistep reaction. Yields of byproduct given; 1.) AcOH, from 70 deg C to 80 deg C, 15 min, 2.) AcOH, from 70 deg C to 80 deg C, 2 h;

DOI:10.1039/a804173c

Reference yield: 67.0%

3-<(4-Oxo-4H-1-benzopyran-3-yl)-methylene>pentan-2,4-dione (57443-91-1) + Propargylamine (2450-71-7) → 1-(6-(2-hydroxybenzoyl)-2-methylindolizin-8-yl)ethanone

Guidance literature:

In 1,2-dichloro-ethane; at 80 ℃; for 1h; Solvent; chemoselective reaction;

DOI:10.1021/acs.orglett.7b00309

upstream raw materials:

3-Formylchromone

acetylacetone

3-formyl-6-methylchromone

Downstream raw materials:

4-(2-hydroxybenzoyl)-1-phenylpyrazole

3-acetyl-5-(2-hydroxybenzoyl)-2-methylpyridine