1H-Pyrazole, 5-(3-chlorophenyl)-4,5-dihydro-1,3-diphenyl-

Base Information

Chemical Name:1H-Pyrazole, 5-(3-chlorophenyl)-4,5-dihydro-1,3-diphenyl-
CAS No.:57488-03-6
Molecular Formula:C21H17ClN2
Molecular Weight:332.832
Hs Code.:
DSSTox Substance ID:DTXSID00369568
Nikkaji Number:J2.270.221A
ChEMBL ID:CHEMBL2132292
Mol file:57488-03-6.mol

Synonyms:3-(3-chlorophenyl)-2,5-diphenyl-3,4-dihydropyrazole;1H-Pyrazole, 5-(3-chlorophenyl)-4,5-dihydro-1,3-diphenyl-;57488-03-6;VU0466992-1;SCHEMBL9650265;CHEMBL2132292;BDBM91549;cid_2729173;DTXSID00369568;CCG-244490;1,3-Diphenyl-5-(3-chlorophenyl)-2-pyrazoline;5-(3-chlorophenyl)-1,3-diphenyl-2-pyrazoline

Suppliers and Price of 1H-Pyrazole, 5-(3-chlorophenyl)-4,5-dihydro-1,3-diphenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrazole, 5-(3-chlorophenyl)-4,5-dihydro-1,3-diphenyl-

Chemical Property:

XLogP3:5.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:332.1080262
Heavy Atom Count:24
Complexity:437

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(N(N=C1C2=CC=CC=C2)C3=CC=CC=C3)C4=CC(=CC=C4)Cl

Technology Process of 1H-Pyrazole, 5-(3-chlorophenyl)-4,5-dihydro-1,3-diphenyl-

There total 4 articles about 1H-Pyrazole, 5-(3-chlorophenyl)-4,5-dihydro-1,3-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 22966-13-8,72758-76-0,5328-73-4
3-(3-chlorophenyl)-1-phenylprop-2-en-1-one

: 100-63-0
phenylhydrazine

: 57488-03-6
1,3-diphenyl-5-(3-chlorophenyl)-2-pyrazoline

Guidance literature:: With bis(triphenylphosphane)copper(I) nitrate; potassium hydroxide; In ethanol; at 20 ℃; for 0.0833333h; Solvent; Sonication;
DOI:10.14233/ajchem.2018.21131

Reference yield: 87.0%

: 22966-13-8,72758-76-0,5328-73-4
3-(3-chlorophenyl)-1-phenylprop-2-en-1-one

: 59-88-1
phenylhydrazine hydrochloride

: 57488-03-6
1,3-diphenyl-5-(3-chlorophenyl)-2-pyrazoline

Guidance literature:: In ethanol; for 3h; Reflux;
DOI:10.1016/j.molstruc.2018.07.052

Reference yield:

: 587-04-2
m-Chlorobenzaldehyde

: 98-86-2
acetophenone

: 57488-03-6
1,3-diphenyl-5-(3-chlorophenyl)-2-pyrazoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol; water / 0.08 h / 0 °C

1.2: 25 °C

2.1: O₄₀PW₁₂^(3-)*2.5Cs⁽¹⁺⁾*0.5H⁽¹⁺⁾ / ethanol / 0.33 h / Green chemistry

With O₄₀PW₁₂^(3-)*2.5Cs⁽¹⁺⁾*0.5H⁽¹⁺⁾; sodium hydroxide; In ethanol; water;
DOI:10.1016/S1872-2067(11)60330-6