2-chloro-N-cyclohexylnicotinamide

Base Information

Chemical Name:2-chloro-N-cyclohexylnicotinamide
CAS No.:57841-70-0
Molecular Formula:C12H15ClN2O
Molecular Weight:238.717
Hs Code.:2933399090
DSSTox Substance ID:DTXSID60389969
Nikkaji Number:J3.022.285G
Wikidata:Q82186288
ChEMBL ID:CHEMBL1861112
Mol file:57841-70-0.mol

Synonyms:2-chloro-N-cyclohexylnicotinamide;57841-70-0;2-chloro-N-cyclohexylpyridine-3-carboxamide;Oprea1_526762;Oprea1_752136;SCHEMBL3165964;CHEMBL1861112;DTXSID60389969;DWMGLWCQLGOYOC-UHFFFAOYSA-N;DNDI902913;MFCD01344059;AKOS000158267;NCGC00329791-01;N-Cyclohexyl-2-chloropyridine-3-carboxamide;CS-0132469;2-Chloro-N-cyclohexyl-pyridine-3-carboxamide;2-chloro-N-cyclohexylnicotinamide, AldrichCPR;EN300-50337;9N-760;E81614;AB01324234-02;Z31484286

Suppliers and Price of 2-chloro-N-cyclohexylnicotinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chloro-N-cyclohexylnicotinamide
1g
$ 310.00

Matrix Scientific
2-Chloro-N-cyclohexylnicotinamide
500mg
$ 237.00

Matrix Scientific
2-Chloro-N-cyclohexylnicotinamide
2.5g
$ 720.00

Crysdot
2-Chloro-N-cyclohexylnicotinamide 95+%
5g
$ 446.00

American Custom Chemicals Corporation
2-CHLORO-N-CYCLOHEXYLNICOTINAMIDE 95.00%
2.5G
$ 932.60

American Custom Chemicals Corporation
2-CHLORO-N-CYCLOHEXYLNICOTINAMIDE 95.00%
1G
$ 692.46

Alfa Aesar
2-Chloro-N-cyclohexylnicotinamide, 99%
5g
$ 42.90

Alfa Aesar
2-Chloro-N-cyclohexylnicotinamide, 99%
1g
$ 22.30

AK Scientific
2-Chloro-N-cyclohexylnicotinamide
250mg
$ 166.00

Total 8 raw suppliers

Chemical Property of 2-chloro-N-cyclohexylnicotinamide

Chemical Property:

PSA：41.99000
LogP:3.18840
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:238.0872908
Heavy Atom Count:16
Complexity:241

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-N-cyclohexylnicotinamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)NC(=O)C2=C(N=CC=C2)Cl

Technology Process of 2-chloro-N-cyclohexylnicotinamide

There total 4 articles about 2-chloro-N-cyclohexylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 10366-35-5
2-chloronicotinamide

: 98-89-5
Cyclohexanecarboxylic acid

: 57841-70-0
N-cyclohexyl-2-chloropyridine-3-carboxamide

Guidance literature:: With copper(I) thiophene-2-carboxylate; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(5-methyl-2-(4-fluorophenyl)pyridine(-1H))-iridium(III) hexafluorophosphate; N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; bathophenanthroline; iodomesitylene diacetate; In 1,4-dioxane; at 20 ℃; for 1h; regioselective reaction; Inert atmosphere; Irradiation;
DOI:10.1038/s41586-018-0234-8

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 108-91-8,157973-60-9
cyclohexylamine

: 57841-70-0
N-cyclohexyl-2-chloropyridine-3-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 25 ℃; for 18h;

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 57841-70-0
N-cyclohexyl-2-chloropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 3 h / 90 °C

2: triethylamine / toluene / 1 h / 50 °C

With thionyl chloride; triethylamine; In toluene;
DOI:10.1016/j.ejmech.2012.03.031