Technology Process of L-Phenylalanine, N-(4-methylbenzoyl)-, methyl ester
There total 5 articles about L-Phenylalanine, N-(4-methylbenzoyl)-, methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(S)-2-(2-((2,6-diisopropylphenyl)carbamoyl)pyrrolidin-1-yl)-4-(pyrrolidin-1-yl)pyridine 1-oxide; benzoic acid;
In
dichloromethane;
at 20 ℃;
for 24h;
enantioselective reaction;
Resolution of racemate;
DOI:10.1021/jacs.0c09075
- Guidance literature:
-
With
hydrogen; nickel(II) acetate tetrahydrate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine);
In
2,2,2-trifluoroethanol;
at 50 ℃;
for 36h;
under 22801.5 Torr;
enantioselective reaction;
Autoclave;
DOI:10.1002/anie.201916534
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere
2: (S)-2-(2-((2,6-diisopropylphenyl)carbamoyl)pyrrolidin-1-yl)-4-(pyrrolidin-1-yl)pyridine 1-oxide; benzoic acid / dichloromethane / 24 h / 20 °C / Resolution of racemate
With
(S)-2-(2-((2,6-diisopropylphenyl)carbamoyl)pyrrolidin-1-yl)-4-(pyrrolidin-1-yl)pyridine 1-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzoic acid;
In
dichloromethane;
DOI:10.1021/jacs.0c09075
