Methyl 3-hydroxy-6-methylpicolinate

Base Information

• Chemical Name: Methyl 3-hydroxy-6-methylpicolinate
• CAS No.: 61548-52-5
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.164
• DSSTox Substance ID: DTXSID60488224
• Wikidata: Q82330752
• Mol file: 61548-52-5.mol

Synonyms:Methyl 3-hydroxy-6-methylpicolinate;61548-52-5;3-Hydroxy-6-Methyl-2-pyridinecarboxylic acid Methyl ester;methyl 3-hydroxy-6-methylpyridine-2-carboxylate;MFCD18254681;Methyl3-hydroxy-6-methylpicolinate;SCHEMBL3947679;DTXSID60488224;XUGRAUKXRVIKQU-UHFFFAOYSA-N;AMY18982;AKOS016011656;DS-7015;SB53637;SY114268;CS-0096410;C75887;EN300-3173448;A849855;Methyl 3-hydroxy-6-methyl-pyridine-2-carboxylate;Z1255438026

Chemical Property of Methyl 3-hydroxy-6-methylpicolinate

Chemical Property:

• Melting Point: 83-84 °C
• Boiling Point: 341.8±37.0 °C(Predicted)
• PKA: 4.69±0.10(Predicted)
• PSA: 59.42000
• Density: 1.235±0.06 g/cm3(Predicted)
• LogP: 0.88220
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 167.058243149
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-hydroxy-6-methylpicolinate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=C(C=C1)O)C(=O)OC

Technology Process of Methyl 3-hydroxy-6-methylpicolinate

There total 3 articles about Methyl 3-hydroxy-6-methylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 2-iodo-6-methyl-3-pyridinol (23003-30-7) + carbon monoxide (201230-82-2) → 3-hydroxy-6-methyl-pyridine-2-carboxylic acid methyl ester (61548-52-5)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; at 100 ℃; for 3h; under 7500.75 Torr;

Reference yield: 75.0%

methanol (67-56-1) + 3-hydroxy-6-methylpicolinaldehyde (66497-42-5) → 3-hydroxy-6-methyl-pyridine-2-carboxylic acid methyl ester (61548-52-5)

Guidance literature:

With sodium cyanide; manganese(IV) oxide; acetic acid; at 20 ℃;

Reference yield:

→ 3-hydroxy-6-methyl-pyridine-2-carboxylic acid methyl ester (61548-52-5)

Guidance literature:

Carbonsaeure 2a, Thionylchlorid, Me.;

upstream raw materials:

methanol

3-hydroxy-6-methylpicolinaldehyde

2-iodo-6-methyl-3-pyridinol

carbon monoxide

Downstream raw materials:

methyl 3-methoxy-6-methylpicolinate

C₁₆H₁₅Cl₂NO₄

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