Prenoverine

Base Information

• Chemical Name: Prenoverine
• CAS No.: 66022-25-1
• Molecular Formula: C₂₅H₂₉NO₂
• Molecular Weight: 375.511
• UNII: PK3852O88V
• DSSTox Substance ID: DTXSID60867131
• Wikidata: Q27286596
• NCI Thesaurus Code: C66466
• ChEMBL ID: CHEMBL2106990
• Mol file: 66022-25-1.mol

Synonyms:Prenoverine;Prenoverine [INN];65236-29-5;UNII-PK3852O88V;PK3852O88V;N-(2-benzhydryloxyethyl)-N-methyl-1-phenoxypropan-2-amine;66022-25-1;SCHEMBL2109974;CHEMBL2106990;DTXSID60867131;Q27286596;(+-)-2'-(Diphenylmethoxy)-N,1-dimethyl-2-phenoxydiethylamine;(- )-2'-(Diphenylmethoxy)-N,1-dimethyl-2-phenoxydiethylamine;N-[2-(Diphenylmethoxy)ethyl]-N-methyl-1-phenoxypropan-2-amine

Chemical Property of Prenoverine

Chemical Property:

• Boiling Point: 489.8±40.0 °C(Predicted)
• PKA: 7.89±0.50(Predicted)
• PSA: 21.70000
• Density: 1.069±0.06 g/cm3(Predicted)
• LogP: 5.19190
• XLogP3: 5.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 10
• Exact Mass: 375.219829168
• Heavy Atom Count: 28
• Complexity: 379

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(COC1=CC=CC=C1)N(C)CCOC(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of Prenoverine

There total 4 articles about Prenoverine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-2-phenoxyethylamine (35205-54-0) → prenoverine (66022-25-1,65236-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: KI, Na₂CO₃ / ethanol / Heating

2: H₂O / Heating

With sodium carbonate; potassium iodide; In ethanol; water;

Reference yield:

1,1'-[(2-chloroethoxy)methylene]bis-benzene (32669-06-0) → prenoverine (66022-25-1,65236-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: KI, Na₂CO₃ / ethanol / Heating

2: H₂O / Heating

With sodium carbonate; potassium iodide; In ethanol; water;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + formic acid (64-18-6) + (2-Benzhydryloxy-ethyl)-(1-methyl-2-phenoxy-ethyl)-amine (66022-31-9) → prenoverine (66022-25-1,65236-29-5)

Guidance literature:

In water; Heating;

upstream raw materials:

formaldehyd

formic acid

(2-Benzhydryloxy-ethyl)-(1-methyl-2-phenoxy-ethyl)-amine

1-methyl-2-phenoxyethylamine