4-(Methoxymethyl)-benzenemethanol

Base Information

• Chemical Name: 4-(Methoxymethyl)-benzenemethanol
• CAS No.: 62172-89-8
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• Hs Code.: 2909499000
• Mol file: 62172-89-8.mol

Synonyms:4-methyloxymethylhydroxymethylhydroxymethylcyclohexane;4-MeOC6H4CH2OH;1,4-benzenedimethanol monomethyl ether;(4-methoxymethylphenyl)methanol;Benzenemethanol,4-(methoxymethyl);4-methoxymethylbenzyl alcohol;

Chemical Property of 4-(Methoxymethyl)-benzenemethanol

Chemical Property:

• Boiling Point: 152 °C(Press: 16 Torr)
• PKA: 14.34±0.10(Predicted)
• PSA: 29.46000
• Density: 1.076 g/cm3(Temp: 17 °C)
• LogP: 1.32530

Purity/Quality:

99%min ^*data from raw suppliers

[4-(methoxymethyl)phenyl]methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Methoxymethyl)-benzenemethanol

There total 10 articles about 4-(Methoxymethyl)-benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

p-methoxymethylbenzoic acid methyl ester (1719-82-0) → 4-methyloxymethylhydroxymethylhydroxymethylcyclohexane (62172-89-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1002/ejoc.200390090

Reference yield: 43.0%

4-(Methoxymethyl)benzoic acid (67003-50-3) → 4-methyloxymethylhydroxymethylhydroxymethylcyclohexane (62172-89-8)

Guidance literature:

With tributylphosphine; diphenylsilane; C₄₅H₂₅F₁₂N₇Ni₂O₉; In 1,4-dioxane; at 100 ℃; for 16h;

DOI:10.1039/c6dt00567e

Reference yield: 24.6%

methanol (67-56-1) + 4-(bromomethyl)benzyl alcohol (71831-21-5) → 4-methyloxymethylhydroxymethylhydroxymethylcyclohexane (62172-89-8)

Guidance literature:

methanol; 4-(bromomethyl)benzyl alcohol; at 20 ℃; for 0.0333333h;

With potassium carbonate; In water; at 20 ℃; for 15h; Reflux;

upstream raw materials:

4-(methoxymethyl)benzaldehyde

1-(chloromethyl)-4-(methoxymethyl)benzene

p-xylylene glycol

dimethyl sulfate

Downstream raw materials:

1-(chloromethyl)-4-(methoxymethyl)benzene

4-(methoxymethyl)benzyl acetate

1-(bromomethyl)-4-(methoxymethyl)benzene

4-(Methoxymethyl)benzoic acid

Refernces

• 1、 Huang, Da-Wei,Liu, Yi-Hung,Peng, Shie-Ming,Liu, Shiuh-Tzung. "Dinickel complexes with anthyridine-based ligands". . p. 8265 - 8271. Retrieved 2016/06/09.
• 2、 Strazzolini, Paolo,Runcio, Antonio. "Oxidation of benzylic alcohols and ethers to carbonyl derivatives by nitric acid in dichloromethane". . p. 526 - 536. Retrieved 2007/10/03.