BIS(2,2,2-TRIFLUOROETHOXY)TRIPHENYLPHOSPHORANE

Base Information

• Chemical Name: BIS(2,2,2-TRIFLUOROETHOXY)TRIPHENYLPHOSPHORANE
• CAS No.: 67696-25-7
• Molecular Formula: C22H19F6O2P
• Molecular Weight: 460.356
• Mol file: 67696-25-7.mol

Synonyms:triphenyl-bis(2,2,2-trifluoroethoxy);triphenyl-bis(2,2,2-trifluoroethoxy)phosphorane;Ph3P(OCH2CF3)2;bis(2,2,2-trifluoroethoxy)triphenylphoshorane;BIS(2,2,2-TRIFLUOROETHOXY)TRIPHENYLPHOSPHORANE;

Chemical Property of BIS(2,2,2-TRIFLUOROETHOXY)TRIPHENYLPHOSPHORANE

Chemical Property:

• Melting Point: 127-129 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 32.05000
• Density: g/cm³
• LogP: 5.50400

Purity/Quality:

99% ^*data from raw suppliers

BIS(2,2,2-TRIFLUOROETHOXY)TRIPHENYLPHOSPHORANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BIS(2,2,2-TRIFLUOROETHOXY)TRIPHENYLPHOSPHORANE

There total 7 articles about BIS(2,2,2-TRIFLUOROETHOXY)TRIPHENYLPHOSPHORANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

sodium 2,2,2-trifluoroethanolate (420-87-1) + triphenylphosphine (603-35-0) → bis(2,2,2-trifluoroethoxy)triphenylphosphorane (67696-25-7)

Guidance literature:

With bromine; In diethyl ether; dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jo01313a008

Reference yield: 86.0%

2,2,2-trifluoroethyl benzenesulfenate (76943-18-5) + triphenylphosphine (603-35-0) → bis(2,2,2-trifluoroethoxy)triphenylphosphorane (67696-25-7)

Guidance literature:

In pentane; for 12h; Ambient temperature;

DOI:10.1021/ja00397a033

Reference yield: 79.0%

2,2,2-trifluoroethanol (75-89-8) + triphenylphosphine (603-35-0) → bis(2,2,2-trifluoroethoxy)triphenylphosphorane (67696-25-7)

Guidance literature:

triphenylphosphine; With bromine; In dichloromethane; at -78 ℃; for 0.166667h; Inert atmosphere;

2,2,2-trifluoroethanol; With triethylamine; In diethyl ether; dichloromethane; at -78 - 20 ℃; for 1.25h; Inert atmosphere;

DOI:10.1021/jm100508m

upstream raw materials:

sodium 2,2,2-trifluoroethanolate

triphenylphosphine

2,2,2-trifluoroethyl phenyl sulfoxide

2,2,2-trifluoroethyl benzenesulfenate

Downstream raw materials:

2,2,2-trifluoroethyl benzoate

((2,2,2-trifluoroethoxy)methyl)benzene

2,2,2-trifluoroethylbutyrate

Triphenylphosphine oxide

Refernces

• 1、 Morieux, Pierre,Salomé, Christophe,Park, Ki Duk,Stables, James P.,Kohn, Harold. "The structure?activity relationship of the 3-Oxy site in the anticonvulsant (R)- N -benzyl 2-acetamido-3-methoxypropionamide". supporting information; experimental part. p. 5716 - 5726. Retrieved 2010/10/03.
• 2、 Yang, Zhen-Yu. "Bis(fluoroalkoxy)triphenylphosphorane: A New Reagent for the Preparation of Fluorinated Ketals". . p. 5696 - 5698. Retrieved 2007/10/02.