Benzenepropanamide, a-chloro-4-(2-methyl-2-phenylpropoxy)-

Base Information

• Chemical Name: Benzenepropanamide, a-chloro-4-(2-methyl-2-phenylpropoxy)-
• CAS No.: 62516-94-3
• Molecular Formula: C19H22ClNO2
• Molecular Weight: 331.842
• Mol file: 62516-94-3.mol

Synonyms:

Chemical Property of Benzenepropanamide, a-chloro-4-(2-methyl-2-phenylpropoxy)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanamide, a-chloro-4-(2-methyl-2-phenylpropoxy)-

There total 8 articles about Benzenepropanamide, a-chloro-4-(2-methyl-2-phenylpropoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-methyl-2-phenylpropyloxy)nitrobenzene (62517-29-7) → 2-chloro-3-<4-(2-methyl-2-phenylpropyloxy)phenyl>propionamide (62516-94-3)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / benzene; ethanol / 760 Torr / Ambient temperature

2: 1.) 33percent NaNO₂/H₂O, conc. HCl, ethyl acrylate, 2.) Cu₂O / 1.) acetone, ice cooling, 2.) 40 deg C, 2 h

3: 2.8 g / 10.7percent NH₃/MeOH / 5 h / 45 °C

With copper(I) oxide; hydrogenchloride; methanol; ammonia; water; hydrogen; ethyl acrylate; sodium nitrite; palladium on activated charcoal; In ethanol; benzene;

Reference yield:

2-methyl-2-phenyl-propan-1-ol (2173-69-5) → 2-chloro-3-<4-(2-methyl-2-phenylpropyloxy)phenyl>propionamide (62516-94-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / NaH / dimethylsulfoxide / 3 h / 60 °C

2: H₂ / 10percent Pd/C / benzene; ethanol / 760 Torr / Ambient temperature

3: 1.) 33percent NaNO₂/H₂O, conc. HCl, ethyl acrylate, 2.) Cu₂O / 1.) acetone, ice cooling, 2.) 40 deg C, 2 h

4: 2.8 g / 10.7percent NH₃/MeOH / 5 h / 45 °C

With copper(I) oxide; hydrogenchloride; methanol; ammonia; water; hydrogen; sodium hydride; ethyl acrylate; sodium nitrite; palladium on activated charcoal; In ethanol; dimethyl sulfoxide; benzene;

Reference yield:

4-chlorobenzonitrile (100-00-5) → 2-chloro-3-<4-(2-methyl-2-phenylpropyloxy)phenyl>propionamide (62516-94-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / NaH / dimethylsulfoxide / 3 h / 60 °C

2: H₂ / 10percent Pd/C / benzene; ethanol / 760 Torr / Ambient temperature

3: 1.) 33percent NaNO₂/H₂O, conc. HCl, ethyl acrylate, 2.) Cu₂O / 1.) acetone, ice cooling, 2.) 40 deg C, 2 h

4: 2.8 g / 10.7percent NH₃/MeOH / 5 h / 45 °C

With copper(I) oxide; hydrogenchloride; methanol; ammonia; water; hydrogen; sodium hydride; ethyl acrylate; sodium nitrite; palladium on activated charcoal; In ethanol; dimethyl sulfoxide; benzene;

upstream raw materials:

4-(2-methyl-2-phenylpropyloxy)aniline

2-propenamide

ethyl 2-chloro-3-[4-(2,2-dimethyl-2-phenylethyloxy)phenyl]propionate

2-methyl-2-phenyl-propan-1-ol

Downstream raw materials:

N-acetyl-2-chloro-3-<4-(2-methyl-2-phenylpropyloxy)phenyl>propionamide