3,3-Dichloro-2-formoxytetrahydropyran

Base Information

• Chemical Name: 3,3-Dichloro-2-formoxytetrahydropyran
• CAS No.: 141942-53-2
• Molecular Formula: C₆H₈Cl₂O₃
• Molecular Weight: 199.034
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID50369250
• Mol file: 141942-53-2.mol

Synonyms:3,3-DICHLORO-2-FORMOXYTETRAHYDROPYRAN;141942-53-2;(3,3-dichlorooxan-2-yl) formate;DTXSID50369250;C11H9F13O2;3,3-Dichlorotetrahydro-2H-pyran-2-yl formate

Chemical Property of 3,3-Dichloro-2-formoxytetrahydropyran

Chemical Property:

• Vapor Pressure: 0.00368mmHg at 25°C
• Refractive Index: 1.4835-1.4855
• Boiling Point: 280.9°Cat760mmHg
• Flash Point: 126.4°C
• PSA: 35.53000
• Density: 1.38g/cm³
• LogP: 2.10570
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 197.9850495
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(C(OC1)OC=O)(Cl)Cl

Technology Process of 3,3-Dichloro-2-formoxytetrahydropyran

There total 1 articles about 3,3-Dichloro-2-formoxytetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,3,3-trichloro-tetrahydropyran (63027-88-3) + formic acid (64-18-6) → 3,3-dichloro-2-formoxytetrahydropyran (141942-53-2)

Guidance literature:

With sodium formate; at 112 ℃; for 0.25h;

Reference yield: 99.0%

3,3-dichloro-2-formoxytetrahydropyran (141942-53-2) → 3,3-dichloro-2-hydroxytetrahydropyran (76043-70-4)

Guidance literature:

In methanol; at 70 - 72 ℃;

Reference yield:

3,3-dichloro-2-formoxytetrahydropyran (141942-53-2) → 2,2-dichloro-1,5-pentanediol (141942-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / methanol / 70 - 72 °C

2: NaBH₄ / ethanol / 120 h / Ambient temperature

With sodium tetrahydroborate; In methanol; ethanol;

upstream raw materials:

2,3,3-trichloro-tetrahydropyran

formic acid

Downstream raw materials:

3,3-dichloro-2-hydroxytetrahydropyran

2,2-dichloro-1,5-pentanediol