N-(2,2,2-Trifluoroethylidene)cyclohexanamine

Base Information

• Chemical Name: N-(2,2,2-Trifluoroethylidene)cyclohexanamine
• CAS No.: 31185-49-6
• Molecular Formula: C8H12 F3 N
• Molecular Weight: 179.1828
• Hs Code.: 2921300090
• Mol file: 31185-49-6.mol

Synonyms:Cyclohexylamine,N-(2,2,2-trifluoroethylidene)- (8CI)

Chemical Property of N-(2,2,2-Trifluoroethylidene)cyclohexanamine

Chemical Property:

• Vapor Pressure: 3.54mmHg at 25°C
• Boiling Point: 157.5°Cat760mmHg
• Flash Point: 49.1°C
• PSA: 12.36000
• Density: 1.18g/cm³
• LogP: 2.95220

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2,2,2-Trifluoroethylidene)cyclohexanamine

There total 2 articles about N-(2,2,2-Trifluoroethylidene)cyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) + ethyl trifluoroacetaldehyde hemiacetal (433-27-2) → 2,2,2-Trifluoraethylidoncyclohexylamin (31185-49-6)

Guidance literature:

In water; at 105 ℃; for 4h;

DOI:10.1021/acs.orglett.9b00128

Reference yield:

2,2,2-trifluoro-1,1-ethanediol (421-53-4) + cyclohexylamine (108-91-8,157973-60-9) → 2,2,2-Trifluoraethylidoncyclohexylamin (31185-49-6)

Guidance literature:

In benzene;

DOI:10.1021/jm00300a044

Reference yield: 76.0%

1,3-DIOXOLANE (646-06-0) + 2,2,2-Trifluoraethylidoncyclohexylamin (31185-49-6) → N-(1-(1,3-dioxolan-2-yl)-2,2,2-trifluoroethyl)cyclohexanamine

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; dimethylglyoxal; at 20 ℃; Molecular sieve; Irradiation; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00128

upstream raw materials:

2,2,2-trifluoro-1,1-ethanediol

cyclohexylamine

ethyl trifluoroacetaldehyde hemiacetal

Refernces

• 1、 Crank,Harding,Szinai. "Perfluoroalkyl carbonyl compounds. 1. Perfluoroaldehyde and perfluorocarboxylic acid derivatives.". . p. 1212 - 1215. Retrieved 2007/10/08.