N2,N2-diMethylpyridine-2,6-diaMine

Base Information

• Chemical Name: N2,N2-diMethylpyridine-2,6-diaMine
• CAS No.: 63763-86-0
• Molecular Formula: C7H11N3
• Molecular Weight: 137.184
• Mol file: 63763-86-0.mol

Synonyms:2-Amino-6-dimethylaminopyridine;2-amino-6-(dimethylamino)pyridine;2-Amino-6-dimethylamino-pyridin;N,N-dimethylpyridine-2,6-diamine;6-dimethylamino-2-amino pyridine;

Chemical Property of N2,N2-diMethylpyridine-2,6-diaMine

Chemical Property:

• Boiling Point: 253.5±20.0 °C(Predicted)
• PKA: 6.21±0.24(Predicted)
• PSA: 42.15000
• Density: 1.115±0.06 g/cm3(Predicted)
• LogP: 1.31100

Purity/Quality:

98%,99%, ^*data from raw suppliers

N2,N2-dimethylpyridine-2,6-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N2,N2-diMethylpyridine-2,6-diaMine

There total 1 articles about N2,N2-diMethylpyridine-2,6-diaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

6-chloropyridin-2-amine (45644-21-1) + dimethyl amine (124-40-3) → 2-amino-6-N,N-dimethylamino pyridine (63763-86-0)

Guidance literature:

With copper(II) sulfate; In ethanol; water; at 180 - 190 ℃; for 38h;

DOI:10.1007/BF00506847

Reference yield:

2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]acetic acid (883985-18-0) + 2-amino-6-N,N-dimethylamino pyridine (63763-86-0) → N-(6-dimethylaminopyridin-2-yl)-2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]acetamide

Guidance literature:

2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]acetic acid; 2-amino-6-N,N-dimethylamino pyridine; With 2-hydroxy-pyridine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 17 - 25 ℃; for 16h;

With sodium hydrogencarbonate; In water; ethyl acetate; N,N-dimethyl-formamide; at 17 - 25 ℃; for 1h;

Reference yield:

2-{4-[7-(2-methoxyethoxy)-6-methoxyquinazolin-4-yloxy]phenyl}acetic acid (883987-69-7) + 2-amino-6-N,N-dimethylamino pyridine (63763-86-0) → N-(6-dimethylaminopyridin-2-yl)-2-{4-[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yloxy]phenyl}acetamide

Guidance literature:

2-{4-[7-(2-methoxyethoxy)-6-methoxyquinazolin-4-yloxy]phenyl}acetic acid; 2-amino-6-N,N-dimethylamino pyridine; With 2-hydroxy-pyridine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 17 - 25 ℃; for 16h;

With sodium hydrogencarbonate; In water; ethyl acetate; N,N-dimethyl-formamide; at 17 - 25 ℃; for 1h;

upstream raw materials:

6-chloropyridin-2-amine

dimethyl amine