2H-2-Benzazepine-2-carboxylic acid, 5-(4-chlorophenyl)-7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4- nitrophenoxy)ethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:2H-2-Benzazepine-2-carboxylic acid, 5-(4-chlorophenyl)-7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4- nitrophenoxy)ethyl]-, 1,1-dimethylethyl ester
CAS No.:649723-01-3
Molecular Formula:C32H34ClN3O7
Molecular Weight:608.091
Hs Code.:

2H-2-Benzazepine-2-carboxylic acid,
5-(4-chlorophenyl)-7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4-
nitrophenoxy)ethyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 2H-2-Benzazepine-2-carboxylic acid, 5-(4-chlorophenyl)-7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4- nitrophenoxy)ethyl]-, 1,1-dimethylethyl ester

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 2H-2-Benzazepine-2-carboxylic acid, 5-(4-chlorophenyl)-7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4- nitrophenoxy)ethyl]-, 1,1-dimethylethyl ester

There total 13 articles about 2H-2-Benzazepine-2-carboxylic acid, 5-(4-chlorophenyl)-7-[[(dimethylamino)carbonyl]oxy]-1,3-dihydro-1-[2-(4- nitrophenoxy)ethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1679-18-1
4-Chlorophenylboronic acid

: 649722-91-8
7-dimethylcarbamoyloxy-1-[2-(4-nitrophenoxy)ethyl]-5-trifluoromethanesulfonyloxy-1,3-dihydrobenzo[c]azepine-2-carboxylic acid tert-butyl ester

: 649723-01-3
5-(4-chloro-phenyl)-7-dimethylcarbamoyloxy-1-[2-(4-nitro-phenoxy)-ethyl]-1,3-dihydro-benzo[c]azepine-2-carboxylic acid tert-butyl ester

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 85 ℃; for 6h;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 649723-01-3
5-(4-chloro-phenyl)-7-dimethylcarbamoyloxy-1-[2-(4-nitro-phenoxy)-ethyl]-1,3-dihydro-benzo[c]azepine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

1.2: HCl / ethyl acetate / 20 °C

2.1: 1.20 g / triethylamine / tetrahydrofuran / 1 h / 20 °C

3.1: LHMDS / tetrahydrofuran / 0.5 h / -78 °C

3.2: 98 percent / tetrahydrofuran / 1 h / -78 °C

4.1: 55 percent / Pd(PPh₃)4; K₃PO₄ / dioxane / 6 h / 85 °C

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; toluene; 1.1: Mitsunobu reaction / 4.1: Suzuki coupling;
DOI:10.1016/S0968-0896(03)00452-8

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 649723-01-3
5-(4-chloro-phenyl)-7-dimethylcarbamoyloxy-1-[2-(4-nitro-phenoxy)-ethyl]-1,3-dihydro-benzo[c]azepine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1.20 g / triethylamine / tetrahydrofuran / 1 h / 20 °C

2.1: LHMDS / tetrahydrofuran / 0.5 h / -78 °C

2.2: 98 percent / tetrahydrofuran / 1 h / -78 °C

3.1: 55 percent / Pd(PPh₃)4; K₃PO₄ / dioxane / 6 h / 85 °C

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; 3.1: Suzuki coupling;
DOI:10.1016/S0968-0896(03)00452-8