L-Valine, N-[[3,5-dibromo-4-[3-fluoro-4-methoxy-5-(1-methylethyl)phenoxy]phenyl] acetyl]-, methyl ester

Base Information

Chemical Name:L-Valine, N-[[3,5-dibromo-4-[3-fluoro-4-methoxy-5-(1-methylethyl)phenoxy]phenyl] acetyl]-, methyl ester
CAS No.:649725-46-2
Molecular Formula:C24H28Br2FNO5
Molecular Weight:589.296
Hs Code.:

Synonyms:

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Chemical Property of L-Valine, N-[[3,5-dibromo-4-[3-fluoro-4-methoxy-5-(1-methylethyl)phenoxy]phenyl] acetyl]-, methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of L-Valine, N-[[3,5-dibromo-4-[3-fluoro-4-methoxy-5-(1-methylethyl)phenoxy]phenyl] acetyl]-, methyl ester

There total 5 articles about L-Valine, N-[[3,5-dibromo-4-[3-fluoro-4-methoxy-5-(1-methylethyl)phenoxy]phenyl] acetyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 649725-45-1
methyl[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenyl]acetic acid

: 6306-52-1
L-valine methylester hydrochloride

: 649725-46-2
L-methyl-N-[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenylacetyl]valinate

Guidance literature:: methyl[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenyl]acetic acid; L-valine methylester hydrochloride; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 24h;

With hydrogenchloride; In DMF (N,N-dimethyl-formamide); water;

Reference yield:

: 649725-42-8
methyl[3,5-dibromo-4-(5-isopropyl-4-methoxy-3-nitrophenoxy)phenyl]acetate

: 649725-46-2
L-methyl-N-[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenylacetyl]valinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 457 mg / sodium hydrosulfite / ethanol / 48 h / Heating

2.1: nitrosonium tetrafluoroborate / CH₂Cl₂ / 1 h / 0 °C

2.2: 205 mg / o-xylene / 1 h / Heating

3.1: 210 mg / aq. LiOH / tetrahydrofuran / 20 °C

4.1: 224 mg / TEA; EDCI; HOBt / dimethylformamide / 24 h / 20 °C

With lithium hydroxide; sodium disulfite; TEA; benzotriazol-1-ol; nitrosonium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.05.049

Reference yield:

: 649725-43-9
methyl[3,5-dibromo-4-(3-amino-5-isopropyl-4-methoxyphenoxy)phenyl]acetate

: 649725-46-2
L-methyl-N-[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenylacetyl]valinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: nitrosonium tetrafluoroborate / CH₂Cl₂ / 1 h / 0 °C

1.2: 205 mg / o-xylene / 1 h / Heating

2.1: 210 mg / aq. LiOH / tetrahydrofuran / 20 °C

3.1: 224 mg / TEA; EDCI; HOBt / dimethylformamide / 24 h / 20 °C

With lithium hydroxide; TEA; benzotriazol-1-ol; nitrosonium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.05.049