methyl[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenyl]acetic acid

Base Information

Chemical Name:methyl[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenyl]acetic acid
CAS No.:649725-45-1
Molecular Formula:C₁₈H₁₇Br₂FO₄
Molecular Weight:476.137
Hs Code.:

Synonyms:methyl[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenyl]acetic acid

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Chemical Property of methyl[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenyl]acetic acid

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Technology Process of methyl[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenyl]acetic acid

There total 4 articles about methyl[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenyl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 649725-44-0
methyl 3,5-dibromo-4-(4-methoxy-5-fluoro-3-isopropylphenoxy)phenylacetate

: 649725-45-1
methyl[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenyl]acetic acid

Guidance literature:: methyl 3,5-dibromo-4-(4-methoxy-5-fluoro-3-isopropylphenoxy)phenylacetate; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 649725-42-8
methyl[3,5-dibromo-4-(5-isopropyl-4-methoxy-3-nitrophenoxy)phenyl]acetate

: 649725-45-1
methyl[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 457 mg / sodium hydrosulfite / ethanol / 48 h / Heating

2.1: nitrosonium tetrafluoroborate / CH₂Cl₂ / 1 h / 0 °C

2.2: 205 mg / o-xylene / 1 h / Heating

3.1: 210 mg / aq. LiOH / tetrahydrofuran / 20 °C

With lithium hydroxide; sodium disulfite; nitrosonium tetrafluoroborate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2007.05.049

Reference yield:

: 649725-43-9
methyl[3,5-dibromo-4-(3-amino-5-isopropyl-4-methoxyphenoxy)phenyl]acetate

: 649725-45-1
methyl[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenyl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: nitrosonium tetrafluoroborate / CH₂Cl₂ / 1 h / 0 °C

1.2: 205 mg / o-xylene / 1 h / Heating

2.1: 210 mg / aq. LiOH / tetrahydrofuran / 20 °C

With lithium hydroxide; nitrosonium tetrafluoroborate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2007.05.049