1,3,4-Oxadiazole-2(3H)-thione, 5-(((2-methyl-4-quinazolinyl)oxy)methyl)-3-((4-phenyl-1-piperazinyl)methyl)-

Base Information

Chemical Name:1,3,4-Oxadiazole-2(3H)-thione, 5-(((2-methyl-4-quinazolinyl)oxy)methyl)-3-((4-phenyl-1-piperazinyl)methyl)-
CAS No.:96548-03-7
Molecular Formula:C₂₃H₂₄N₆O₂S
Molecular Weight:448.549
Hs Code.:
DSSTox Substance ID:DTXSID10242318
Wikidata:Q83125971

Synonyms:BRN 5667561;1,3,4-Oxadiazole-2(3H)-thione, 5-(((2-methyl-4-quinazolinyl)oxy)methyl)-3-((4-phenyl-1-piperazinyl)methyl)-;96548-03-7;DTXSID10242318

Suppliers and Price of 1,3,4-Oxadiazole-2(3H)-thione, 5-(((2-methyl-4-quinazolinyl)oxy)methyl)-3-((4-phenyl-1-piperazinyl)methyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3,4-Oxadiazole-2(3H)-thione, 5-(((2-methyl-4-quinazolinyl)oxy)methyl)-3-((4-phenyl-1-piperazinyl)methyl)-

Chemical Property:

XLogP3:4.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:448.16814520
Heavy Atom Count:32
Complexity:679

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC2=CC=CC=C2C(=N1)OCC3=NN(C(=S)O3)CN4CCN(CC4)C5=CC=CC=C5

Technology Process of 1,3,4-Oxadiazole-2(3H)-thione, 5-(((2-methyl-4-quinazolinyl)oxy)methyl)-3-((4-phenyl-1-piperazinyl)methyl)-

There total 3 articles about 1,3,4-Oxadiazole-2(3H)-thione, 5-(((2-methyl-4-quinazolinyl)oxy)methyl)-3-((4-phenyl-1-piperazinyl)methyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 92-54-6
4-phenyl-1-piperazine

: 96547-98-7
5-(2-Methyl-quinazolin-4-yloxymethyl)-3H-[1,3,4]oxadiazole-2-thione

: 96548-03-7
5-(2-Methyl-quinazolin-4-yloxymethyl)-3-(4-phenyl-piperazin-1-ylmethyl)-3H-[1,3,4]oxadiazole-2-thione

Guidance literature:: In ethanol; water; for 0.0833333h; Heating;

Reference yield:

: 96547-95-4
ethyl (2-methylquinazol-4-oxy)acetate

: 96548-03-7
5-(2-Methyl-quinazolin-4-yloxymethyl)-3-(4-phenyl-piperazin-1-ylmethyl)-3H-[1,3,4]oxadiazole-2-thione

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / hydrazine hydrate / ethanol / 6 h / Heating

2: 60 percent / KOH / ethanol; H₂O / 20 h / Heating

3: 60 percent / ethanol; H₂O / 0.08 h / Heating

With potassium hydroxide; hydrazine hydrate; In ethanol; water;

Reference yield:

: 1769-24-0
4-hydroxy-2-methylquinazoline

: 96548-03-7
5-(2-Methyl-quinazolin-4-yloxymethyl)-3-(4-phenyl-piperazin-1-ylmethyl)-3H-[1,3,4]oxadiazole-2-thione

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / K₂CO₃ / acetone / 20 h / Heating

2: 90 percent / hydrazine hydrate / ethanol / 6 h / Heating

3: 60 percent / KOH / ethanol; H₂O / 20 h / Heating

4: 60 percent / ethanol; H₂O / 0.08 h / Heating

With potassium hydroxide; potassium carbonate; hydrazine hydrate; In ethanol; water; acetone;