tert-Butyl 4-[4-(chloroMethyl)thiazol-2-yl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-Butyl 4-[4-(chloroMethyl)thiazol-2-yl]piperidine-1-carboxylate
CAS No.:650579-82-1
Molecular Formula:C14H21ClN2O2S
Molecular Weight:316.852
Hs Code.:
Mol file:650579-82-1.mol

Synonyms:4-(4-chloromethyl-thiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester;1-(1,1-dimethylethyl) 4-(4-chloromethyl-2-thiazolyl)-1-piperidinecarboxylate;1-Piperidinecarboxylic acid, 4-[4-(chloromethyl)-2-thiazolyl]-,1,1-dimethylethyl ester;

Suppliers and Price of tert-Butyl 4-[4-(chloroMethyl)thiazol-2-yl]piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
tert-Butyl4-[4-(chloroMethyl)thiazol-2-yl]piperidine-1-carboxylate
25g
$ 600.00

Total 7 raw suppliers

Chemical Property of tert-Butyl 4-[4-(chloroMethyl)thiazol-2-yl]piperidine-1-carboxylate

Chemical Property:

PSA：70.67000
LogP:3.93430

Purity/Quality:

NLT 98% ^*data from raw suppliers

tert-Butyl4-[4-(chloroMethyl)thiazol-2-yl]piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-Butyl 4-[4-(chloroMethyl)thiazol-2-yl]piperidine-1-carboxylate

There total 5 articles about tert-Butyl 4-[4-(chloroMethyl)thiazol-2-yl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.7%

: 214834-18-1
tert-butyl 4-carbamothioylpiperidine-1-carboxylate

: 534-07-6
1,3-Dichloroacetone

: 650579-82-1
1,1-dimethylethyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate

Guidance literature:: With magnesium sulfate; magnesium carbonate; In acetone; for 12h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmcl.2017.10.046

Reference yield:

: 864068-79-1
tert- butyl 4-(4-(hydroxymethyl)thiazol-2-yl)piperidine-1-carboxylate

: 650579-82-1
1,1-dimethylethyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 39546-32-2
4-carboxamidopiperidine

: 650579-82-1
1,1-dimethylethyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / dichloromethane / 2 h / 20 °C

2: Lawessons reagent / dichloromethane; 1,2-dimethoxyethane / 1.33 h / 20 °C

3: magnesium sulfate; magnesium carbonate / acetone / Reflux

With Lawessons reagent; magnesium sulfate; magnesium carbonate; dmap; In 1,2-dimethoxyethane; dichloromethane; acetone;