7-Hydroxy-4-methoxychromen-2-one

Base Information

Chemical Name:7-Hydroxy-4-methoxychromen-2-one
CAS No.:65692-17-3
Molecular Formula:C10H8O4
Molecular Weight:206.19500
Hs Code.:2932209090
DSSTox Substance ID:DTXSID70420670
Nikkaji Number:J817.018E
ChEMBL ID:CHEMBL2391651
Mol file:65692-17-3.mol

Synonyms:7-hydroxy-4-methoxychromen-2-one;CHEMBL2391651;4-Methoxy-7-hydroxycoumarin;SCHEMBL664161;DTXSID70420670;BDBM50435940;AKOS022643892

Suppliers and Price of 7-Hydroxy-4-methoxychromen-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of 7-Hydroxy-4-methoxychromen-2-one

Chemical Property:

Melting Point:272-273 °C
Boiling Point:430.4±45.0 °C(Predicted)
PKA:7.71±0.20(Predicted)
PSA：59.67000
Density:1.40±0.1 g/cm3(Predicted)
LogP:1.64500
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:192.04225873
Heavy Atom Count:14
Complexity:271

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=O)OC2=C1C=CC(=C2)O

Technology Process of 7-Hydroxy-4-methoxychromen-2-one

There total 9 articles about 7-Hydroxy-4-methoxychromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 67-56-1
methanol

: 1983-81-9
4,7-dihydroxycoumarin

: 65692-17-3
4-methoxy-7-hydroxy-2H-chromen-2-one

Guidance literature:: With sulfuric acid; for 3h; Reflux;
DOI:10.1002/cjoc.201500620

Reference yield: 25.0%

: 1983-81-9
4,7-dihydroxycoumarin

: 74-88-4
methyl iodide

: 65692-17-3
4-methoxy-7-hydroxy-2H-chromen-2-one

Guidance literature:: With potassium carbonate; In acetone; for 8h; Reflux;
DOI:10.1021/jm100757r

Reference yield:

: 108-46-3
recorcinol

: 65692-17-3
4-methoxy-7-hydroxy-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: zinc(II) chloride; trichlorophosphate / 12 h / 60 - 65 °C

2: potassium carbonate / acetone / 8 h / Reflux

With potassium carbonate; zinc(II) chloride; trichlorophosphate; In acetone;
DOI:10.1021/jm100757r