2-Chloro-3-(methylthio)pyridine

Base Information

• Chemical Name: 2-Chloro-3-(methylthio)pyridine
• CAS No.: 65753-48-2
• Molecular Formula: C6H6ClNS
• Molecular Weight: 159.63700
• DSSTox Substance ID: DTXSID60500970
• Nikkaji Number: J2.329.508C
• Wikidata: Q82353032
• Mol file: 65753-48-2.mol

Synonyms:2-Chloro-3-(methylthio)pyridine;65753-48-2;2-Chloro-3-methylsulfanylpyridine;2-Chloro-3-(methylsulfanyl)pyridine;Pyridine, 2-chloro-3-(methylthio)-;SCHEMBL924067;DTXSID60500970;MFCD22543683;AKOS023832509;CS-0194920;E92419;EN300-138152

Chemical Property of 2-Chloro-3-(methylthio)pyridine

Chemical Property:

• PSA: 38.19000
• LogP: 2.45690
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 158.9909481
• Heavy Atom Count: 9
• Complexity: 89.1

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-3-(methylthio)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CSC1=C(N=CC=C1)Cl

Technology Process of 2-Chloro-3-(methylthio)pyridine

There total 15 articles about 2-Chloro-3-(methylthio)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chloropyridine (109-09-1) + Dimethyldisulphide (624-92-0) → 2-chloro-3-(methylthio)pyridine (65753-48-2)

Guidance literature:

2-chloropyridine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1.5h; Inert atmosphere;

Dimethyldisulphide; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1039/c0ob00734j

Reference yield: 71.0%

2-chloropyridine (109-09-1) + Dimethyldisulphide (624-92-0) → 2,3-bis(methylthio)pyridine (69212-36-8) + 2-chloro-3-(methylthio)pyridine (65753-48-2)

Guidance literature:

2-chloropyridine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1.5h; Inert atmosphere;

Dimethyldisulphide; In tetrahydrofuran; for 20h; Reflux;

DOI:10.1039/c0ob00734j

Reference yield: 60.0%

3-bromo-2-chloropyridine (52200-48-3) + Dimethyldisulphide (624-92-0) → 2-chloro-3-(methylthio)pyridine (65753-48-2) + 3-bromo-2-chloro-4-methylsulfanyl-pyridine

Guidance literature:

3-bromo-2-chloropyridine; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

Dimethyldisulphide; In tetrahydrofuran; at -78 ℃;

DOI:10.1055/s-2004-831337

upstream raw materials:

2,3-dichloro-pyridine

sodium thiomethoxide

carbon disulfide

3-methylsulfanyl-pyridine N-oxide

Downstream raw materials:

2-chloro-3-methylsulphonyl-pyridine

2-(3-tert-butylamino-2-hydroxypropoxy)-3-methylthiopyridine hydrogen maleate

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