7-aza-N-indolyldiphenylphosphine

Base Information

• Chemical Name: 7-aza-N-indolyldiphenylphosphine
• CAS No.: 663219-75-8
• Molecular Formula: C19H15N2P
• Molecular Weight: 302.31000
• Mol file: 663219-75-8.mol

Synonyms:1-diphenylphosphino-7-azaindole;7-aza-N-indolyldiphenylphosphine;1H-Pyrrolo[2,3-b]pyridine,1-(diphenylphosphino);

Chemical Property of 7-aza-N-indolyldiphenylphosphine

Chemical Property:

• Boiling Point: 474.3±37.0 °C(Predicted)
• PKA: 4.32±0.30(Predicted)
• PSA: 31.41000
• LogP: 3.93230

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-aza-N-indolyldiphenylphosphine

There total 1 articles about 7-aza-N-indolyldiphenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

7-Azaindole (271-63-6) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → 7-aza-N-indolyldiphenylphosphine (663219-75-8)

Guidance literature:

7-Azaindole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;

chloro-diphenylphosphine; In tetrahydrofuran; hexane; for 4h; Further stages.;

DOI:10.1039/b309882f

Reference yield: 98.0%

dichloro(1,5-cyclooctadiene)palladium(II) (12107-56-1) + dichloromethane (75-09-2) + 7-aza-N-indolyldiphenylphosphine (663219-75-8) → [PdCl2(κ(2)P,N-7-aza-N-indolyldiphenylphosphine)]*CH2Cl2

Guidance literature:

In dichloromethane; under N2 or Ar atm. using Schlenk techniques; PdCl2(cod) added to soln. of 7-aza-N-indolyl phosphine ligand in CH2Cl2; stirred for 2 h; half of the solvent evapd. (vac.); hexane added; ppt. filtered; washed (hexane); dried (vac.); recrystd. (CH2Cl2-hexane); elem. anal.;

DOI:10.1039/b309882f

Reference yield: 98.0%

dichloro( 1,5-cyclooctadiene)platinum(ll) (12080-32-9) + dichloromethane (75-09-2) + 7-aza-N-indolyldiphenylphosphine (663219-75-8) → [PtCl2(κ(2)P,N-7-aza-N-indolyldiphenylphosphine)]*0.5CH2Cl2

Guidance literature:

In dichloromethane; under N2 or Ar atm. using Schlenk techniques; PtCl2(cod) added to soln. of 7-aza-N-indolyl phosphine ligand in CH2Cl2; stirred for 2 h; half of the solvent evapd. (vac.); hexane added; ppt. filtered; washed (hexane); dried (vac.); recrystd. (CH2Cl2-hexane); elem. anal.;

DOI:10.1039/b309882f

upstream raw materials:

7-Azaindole

chloro-diphenylphosphine

Downstream raw materials:

[RhCl(CO)(κ(2)P,N-7-aza-N-indolyldiphenylphosphine)]

[PdCl2(κ(2)P,N-7-aza-N-indolyldiphenylphosphine)]

[PtClPh(1-diphenylphosphino-7-azaindole-P,N)]

[PtCl₂(1-diphenylphosphino-7-azaindole-P,N)]

Refernces