Methyl 4-amino-5-iodo-2-methylbenzoate

Base Information

• Chemical Name: Methyl 4-amino-5-iodo-2-methylbenzoate
• CAS No.: 672293-33-3
• Molecular Formula: C9H10INO2
• Molecular Weight: 291.088
• Mol file: 672293-33-3.mol

Synonyms:4-amino-5-iodo-2-methylbenzoic acid methyl ester;methyl 4-amino-2-methyl-5-iodobenzoate;methyl 4-amino-3-iodo-6-methylbenzoate;

Chemical Property of Methyl 4-amino-5-iodo-2-methylbenzoate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 366.952oC at 760 mmHg
• PKA: 0.53±0.10(Predicted)
• Flash Point: 175.726oC
• PSA: 52.32000
• Density: 1.733g/cm3
• LogP: 2.54960
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

Methyl4-amino-5-iodo-2-methylbenzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-amino-5-iodo-2-methylbenzoate

There total 5 articles about Methyl 4-amino-5-iodo-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 4-amino-2-methylbenzoate (6933-47-7) → methyl 4-amino-3-iodo-6-methylbenzoate (672293-33-3)

Guidance literature:

With Iodine monochloride; calcium carbonate; at 20 ℃; for 24h;

DOI:10.1016/j.bmcl.2007.12.038

Reference yield:

methanol (67-56-1) + 4-Amino-2-methyl-benzoyl chloride (90531-76-3) → methyl 4-amino-3-iodo-6-methylbenzoate (672293-33-3)

Guidance literature:

With Iodine monochloride; calcium carbonate; In water; at 20 ℃; for 24h;

DOI:10.1016/j.bmcl.2011.04.011

Reference yield:

2-methyl-4-nitrobenzoyl chloride (30459-70-2) → methyl 4-amino-3-iodo-6-methylbenzoate (672293-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on carbon; hydrogen / methanol / 24 h / 20 °C / 760.05 Torr

2: Iodine monochloride; calcium carbonate / water / 24 h / 20 °C

With palladium on carbon; hydrogen; Iodine monochloride; calcium carbonate; In methanol; water;

DOI:10.1016/j.bmcl.2011.04.011

upstream raw materials:

methyl 4-amino-2-methylbenzoate

methanol

4-Amino-2-methyl-benzoyl chloride

2-methyl-4-nitrobenzoyl chloride

Downstream raw materials:

methyl 4-acetamido-5-iodo-2-methylbenzoate

methyl 6-methyl-3-phenethyl-2-triethylsilyl-1H-indole-5-carboxylate

5-(methoxycarbonyl)-6-methyl-3-phenethyl-1H-indole-2-carboxylic acid

methyl 4-amino-2,5-dimethylbenzoate

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