TRIS(2,2,2-TRIFLUOROETHYL)PHOSPHATE

Base Information

• Chemical Name: TRIS(2,2,2-TRIFLUOROETHYL)PHOSPHATE
• CAS No.: 358-63-4
• Molecular Formula: C6H6F9O4P
• Molecular Weight: 344.071
• Hs Code.: 29199000
• Mol file: 358-63-4.mol

Synonyms:NSC 191836;Tris(2,2,2-trifluoroethyl) phosphate;

Chemical Property of TRIS(2,2,2-TRIFLUOROETHYL)PHOSPHATE

Chemical Property:

• Vapor Pressure: 1.48mmHg at 25°C
• Melting Point: -22℃
• Refractive Index: 1.3200 (20℃)
• Boiling Point: 176.2 °C at 760 mmHg
• Flash Point: 60.4 °C
• PSA: 54.57000
• Density: 1.564 g/cm³
• LogP: 3.83120

Purity/Quality:

98% ^*data from raw suppliers

Tris(2,2,2-trifluoroethyl) Phosphate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRIS(2,2,2-TRIFLUOROETHYL)PHOSPHATE

There total 21 articles about TRIS(2,2,2-TRIFLUOROETHYL)PHOSPHATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tris(2,2,2-trifluoroethyl)phosphite (370-69-4) → tris(2,2,2-trifluoroethyl) phosphate (358-63-4)

Guidance literature:

oxidation;

Reference yield: 93.2%

2,2,2-trifluoroethanol (75-89-8) → tris(2,2,2-trifluoroethyl) phosphate (358-63-4)

Guidance literature:

With 1H-imidazole; trichlorophosphate; In dichloromethane; at 0 - 45 ℃; for 3h; Large scale;

Reference yield: 42.0%

tris(2,2,2-trifluoroethyl)phosphite (370-69-4) + oxiranyl-methanol (556-52-5) → tris(2,2,2-trifluoroethyl) phosphate (358-63-4) + 2,7-Bis-bromomethyl-5-(2,2,2-trifluoro-ethoxy)-1,4,6,9-tetraoxa-5λ5-phospha-spiro[4.4]nonane + 4-Bromomethyl-2,2,2-tris-(2,2,2-trifluoro-ethoxy)-2λ5-[1,3,2]dioxaphospholane

Guidance literature:

With bromine; triethylamine; In diethyl ether; 1.) -50 deg to -60 deg C, 1.5 h, 2.) 20 deg C, 12 h;

upstream raw materials:

2,2,2-trifluoroethanol

tris(2,2,2-trifluoroethyl)phosphite

pentakis(2,2,2-trifluoroethoxy)phosphorane

bromal

Downstream raw materials:

1,1,1-trifluoro-2-iodoethane

Difluor-tris-<2,2,2-trifluor-ethoxy>-phosphoran

di-(2,2,2-trifluoroethyl)chlorophosphate

Refernces

• 1、 Klaehn, John R.,Rollins, Harry W.,McNally, Joshua S.,Arulsamy, Navamoney,Dufek, Eric J.. "Phosphoranimines containing cationic N-imidazolinium moieties". . p. 254 - 265. Retrieved 2017.
• 2、 -. "Preparation method of cefprozil". Paragraph 0017. . Retrieved 2019/04/14.