Dimethyl methylphosphoramidate

Base Information

• Chemical Name: Dimethyl methylphosphoramidate
• CAS No.: 52420-88-9
• Molecular Formula: C3H10NO3P
• Molecular Weight: 139.091
• DSSTox Substance ID: DTXSID70200439
• Nikkaji Number: J387.616K
• Mol file: 52420-88-9.mol

Synonyms:Dimethyl methylphosphoramidate;52420-88-9;Phosphoramidic acid, methyl-, dimethyl ester;N-dimethoxyphosphorylmethanamine;SCHEMBL3486984;DTXSID70200439;AKOS006277773;Methylaminophosphonic acid dimethyl ester;(DIMETHOXYPHOSPHORYL)(METHYL)AMINE;FT-0762613

Chemical Property of Dimethyl methylphosphoramidate

Chemical Property:

• Vapor Pressure: 7.5mmHg at 25°C
• Boiling Point: 136.1°Cat760mmHg
• Flash Point: 36.1°C
• PSA: 57.37000
• Density: 1.124g/cm³
• LogP: 0.99760
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 139.03983018
• Heavy Atom Count: 8
• Complexity: 96.7

Purity/Quality:

97% ^*data from raw suppliers

DIMETHYL METHYLPHOSPHORAMIDATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNP(=O)(OC)OC

Technology Process of Dimethyl methylphosphoramidate

There total 6 articles about Dimethyl methylphosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methanol (67-56-1) + 1,3-dimethyl-2-methylamino-1,3,2-diazaphospholidine-2,4,5-trione (102146-42-9) → N,N'-dimethyloxamide (615-35-0) + dimethyl N-methylphosphoramidate (52420-88-9)

Guidance literature:

for 0.5h; Heating;

DOI:10.1039/P29860000017

Reference yield: 63.0%

1,3-dimethyl-2-methylamino-1,3,2-diazaphospholidine-2,4,5-trione (102146-42-9) → N,N'-dimethyloxamide (615-35-0) + dimethyl N-methylphosphoramidate (52420-88-9)

Guidance literature:

In methanol; Heating;

DOI:10.1039/P29860000017

Reference yield:

methanol (67-56-1) + N-methyl-N-acetyldimethylphosphoramidate (82134-80-3) → N-methyl-acetamide (79-16-3) + trimethyl phosphite (512-56-1) + acetic acid methyl ester (79-20-9) + dimethyl N-methylphosphoramidate (52420-88-9)

Guidance literature:

With hydrogenchloride; at 25 ℃; Rate constant; Product distribution;

DOI:10.1021/jo00166a019

upstream raw materials:

methanol

diphenyl methylphosphoramidate

N-methyl-N-acetyldimethylphosphoramidate

1,3-dimethyl-2-methylamino-1,3,2-diazaphospholidine-2,4,5-trione

Downstream raw materials:

deuteromethanol

dimethylphosphoric acid

methylamine

Refernces

• 1、 Hendrickse, T. F.,Modro, T. A.. "Phosphoric-Carboxylic Imides. V. Reaction with Grignard Reagents". . p. 247 - 250. Retrieved 2007/10/02.
• 2、 Kasparek, Frantisek,Mollin, Jiri. "SOLVOLYSIS OF DIPHENYL AMIDOPHOSPHATES IN AQUEOUS ALCOHOLIC MEDIA". . p. 386 - 396. Retrieved 2007/10/02.