5-[(3,4,5-Trimethoxyphenyl)methyl]pyrimidine-2,4,6-triamine

Base Information

Chemical Name:5-[(3,4,5-Trimethoxyphenyl)methyl]pyrimidine-2,4,6-triamine
CAS No.:73576-24-6
Molecular Formula:C14H19N5O3
Molecular Weight:305.337
Hs Code.:
ChEMBL ID:CHEMBL149408
DSSTox Substance ID:DTXSID70505855
Wikidata:Q82361231

Synonyms:CHEMBL149408;73576-24-6;DTXSID70505855;5-[(3,4,5-Trimethoxyphenyl)methyl]pyrimidine-2,4,6-triamine;BDBM50404475

Suppliers and Price of 5-[(3,4,5-Trimethoxyphenyl)methyl]pyrimidine-2,4,6-triamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[(3,4,5-Trimethoxyphenyl)methyl]pyrimidine-2,4,6-triamine

Chemical Property:

XLogP3:0.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:305.14878949
Heavy Atom Count:22
Complexity:322

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)CC2=C(N=C(N=C2N)N)N

Technology Process of 5-[(3,4,5-Trimethoxyphenyl)methyl]pyrimidine-2,4,6-triamine

There total 3 articles about 5-[(3,4,5-Trimethoxyphenyl)methyl]pyrimidine-2,4,6-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 343221-00-1
2-cyano-(3,4,5-trimethoxy)hydrocinnamonirile

: 113-00-8
guanidine nitrate

: 73576-24-6
2,4,6-triamino-5-(3,4,5-trimethoxybenzyl)pyrimidine

Guidance literature:: In ethanol; for 3h; Heating;
DOI:10.1021/jm00179a012

Reference yield: 60.0%

: 343221-00-1
2-cyano-(3,4,5-trimethoxy)hydrocinnamonirile

: 50-01-1
guanidine hydrochloride

: 73576-24-6
2,4,6-triamino-5-(3,4,5-trimethoxybenzyl)pyrimidine

Guidance literature:: With sodium; In ethanol; for 48h; Heating;
DOI:10.1002/hlca.19800630223

Reference yield:

: 39667-14-6
2,6-dimethoxy-4-<(N,N-dimethylamino)methyl>phenol

: 73576-24-6
2,4,6-triamino-5-(3,4,5-trimethoxybenzyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: ethane-1,2-diol / 120 - 160 °C

2: 1.) NaOMe / 1.) DMSO

With sodium methylate; In ethylene glycol;
DOI:10.1021/jm00179a012