Cyclohexanone, 3-(trimethylsilyl)-

Base Information

• Chemical Name: Cyclohexanone, 3-(trimethylsilyl)-
• CAS No.: 7531-60-4
• Molecular Formula: C9H18OSi
• Molecular Weight: 170.327
• DSSTox Substance ID: DTXSID90450010
• Nikkaji Number: J494.920J
• Mol file: 7531-60-4.mol

Synonyms:Cyclohexanone, 3-(trimethylsilyl)-;7531-60-4;3-trimethylsilylcyclohexan-1-one;3-trimethylsilylcyclohexanone;3-(Trimethylsilyl)cyclohexanone;SCHEMBL3438244;DTXSID90450010

Chemical Property of Cyclohexanone, 3-(trimethylsilyl)-

Chemical Property:

• PSA: 17.07000
• LogP: 2.83790
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 170.112691728
• Heavy Atom Count: 11
• Complexity: 157

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)C1CCCC(=O)C1

Technology Process of Cyclohexanone, 3-(trimethylsilyl)-

There total 30 articles about Cyclohexanone, 3-(trimethylsilyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

cyclohexenone (930-68-7) + 1,1,1,2,2,2-hexamethyldisilane (1450-14-2) → 3-trimethylsilylcyclohexan-1-one (7531-60-4)

Guidance literature:

1,1,1,2,2,2-hexamethyldisilane; With methyllithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; cooling;

cyclohexenone; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; at -78 ℃; for 0.166667h; Further stages.;

DOI:10.1039/b314923d

Reference yield: 87.0%

chloro-trimethyl-silane (75-77-4) + cyclohexenone (930-68-7) → 3-trimethylsilylcyclohexan-1-one (7531-60-4)

Guidance literature:

With lithium dilallyl cuprate; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4039(00)95114-1

Reference yield: 82.0%

5-trimethylsilyl-2-cyclohexanone (56917-71-6) → 3-trimethylsilylcyclohexan-1-one (7531-60-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)92189-1

upstream raw materials:

chloro-trimethyl-silane

cyclohexenone

1,1,1,2,2,2-hexamethyldisilane

trimethylsilyllithium

Downstream raw materials:

1-Butyl-3-trimethylsilanyl-cyclohexanol

3-(trimethylsilyl)cyclohexanone-2,2,6,6-d₄

trans-3-(trimethylsilyl)cyclohexanol

cis-3-(trimethylsilyl)cyclohexanol