2-Propynoic acid, 3-(3-chlorophenyl)-, methyl ester

Base Information

Chemical Name:2-Propynoic acid, 3-(3-chlorophenyl)-, methyl ester
CAS No.:7572-40-9
Molecular Formula:C10H7ClO2
Molecular Weight:194.617
Hs Code.:
DSSTox Substance ID:DTXSID60485394
Wikidata:Q82324545

Synonyms:7572-40-9;2-Propynoic acid, 3-(3-chlorophenyl)-, methyl ester;SCHEMBL11544870;DTXSID60485394;AKOS013859488;(3-Chloro-phenyl)-propynoic acid methyl ester

Suppliers and Price of 2-Propynoic acid, 3-(3-chlorophenyl)-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-Propynoic acid, 3-(3-chlorophenyl)-, methyl ester

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:194.0134572
Heavy Atom Count:13
Complexity:248

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C#CC1=CC(=CC=C1)Cl

Technology Process of 2-Propynoic acid, 3-(3-chlorophenyl)-, methyl ester

There total 10 articles about 2-Propynoic acid, 3-(3-chlorophenyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 67-56-1
methanol

: 2-bromo-1-(3-chlorophenyl)-3,3-difluorocyclopropene

: 7572-40-9
methyl 3-(3-chlorophenyl)prop-2-ynoate

Guidance literature:: Heating;

Reference yield: 67.0%

: 766-83-6
m-chlorophenylacetylene

: 79-22-1
methyl chloroformate

: 7572-40-9
methyl 3-(3-chlorophenyl)prop-2-ynoate

Guidance literature:: m-chlorophenylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

methyl chloroformate; In tetrahydrofuran; hexane; at -78 ℃; for 2h;
DOI:10.1021/acs.joc.8b01493

Reference yield:

: 625-99-0
3-iodochlorobenzene

: 922-67-8
propynoic acid methyl ester

: 7572-40-9
methyl 3-(3-chlorophenyl)prop-2-ynoate

Guidance literature:: 3-iodochlorobenzene; propynoic acid methyl ester; With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In tetrahydrofuran; for 0.0833333h; Inert atmosphere;

With copper(l) iodide; In tetrahydrofuran; at 65 ℃; for 8h; Inert atmosphere;
DOI:10.1021/acs.orglett.9b02016